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Pancreatic cancer is one of the most aggressive solid malignancies prone to metastasis. Epithelial-mesenchymal transition (EMT) contributes to cancer invasiveness and drug resistance. In this study, we investigated whether HS-173, a novel PI3K inhibitor blocked the process of EMT in pancreatic cancer. HS-173 inhibited the growth of pancreatic cancer cells in a dose- and time-dependent manner. M...
Hepatic stellate cells (HSCs) are the primary source of matrix components in liver disease such as fibrosis. Phosphatidylinositol 3-kinase (PI3K) signaling in HSCs has been shown to induce fibrogenesis. In this study, we evaluated the anti-fibrotic activity of a novel imidazopyridine analogue (HS-173) in human HSCs as well as mouse liver fibrosis. HS-173 strongly suppressed the growth and proli...
In order to help the readers stay up-to-date in field, each issue of Progress Photovoltaics will contain a list recently published journal articles that are most relevant its aims and scope. This is drawn from an extremely wide range journals, including IEEE Journal Photovoltaics, Solar Energy Materials Cells, Renewable Energy, Sustainable Reviews, Applied Physics Letters. To assist readers, se...
1 Duane and Patterson, Proc. Nat. Acad. Sci., Washington, Sept. 1920; Phys. Rev., Dec. 1920, p. 526. 2 Coster, Z. Phys., 5, 1921 (139); also 6, 1921 (185). 3 De Broglie and Dauvillier, Paris, C. R., 173, p. 137. Dauvillier, Ibid., 172, also 173, p. 647, also other papers in this volume. 4 Smfkal, Z. Phys., 5, 1921 (91, 121). Also 4, 1921. 5Wentzel, Ibid., 6, 1921 (2). Coster, Ibid., 5, 1921 (14...
The dwarf planet Eris (2003 UB313, formerly known also as “Xena”) is the largest KBO up to now discovered. Despite being larger than Pluto and bearing many similarities with it, it has not been possible insofar to detect any significant variability in its light curve, preventing the determination of its period
BACKGROUND Although young age is considered a risk factor for adverse events related to procedural sedation and analgesia (PSA), data in very young children (<2 years of age) are lacking. AIMS The main objective of our study is to describe PSA in children <2 years of age in an inner city tertiary care pediatric emergency department (PED). METHODS We conducted a retrospective chart review fr...
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