Asparaginases are the cornerstone therapy of many successful combination regimens for the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in children and adolescents. The aim of this work was to produce recombinant Erwinia carotovora L-asparaginase II in Escherichia coli fed-batch cultures. Using a robust fed-batch technique with pre-determined exponential feeding ra...

All drugs should be given with caution to pregnant or breast feeding women. Recent concern about the role of salicylates in the aetiology of Reye's syndrome has prompted the DHSS to restrict the use of aspirin in children. The case of a 9 week old breast fed infant whose serum contained 0.47 mmol/l of salicylate is reported. Her mother was taking aspirin 2.4 g/day, and it is concluded that sali...

We investigated the dose- and time-dependent effect of insulin infusion on peripheral and portal plasma leptin concentrations in normal rats. Three groups were studied: group I: euglycemic (6 mmol/l) insulin (6 mU ⋅ kg-1 ⋅ min-1) clamps for 0, 2, 4, 12, and 24 h; group II: euglycemic insulin (18 mU ⋅ kg-1 ⋅ min-1) clamp for 2 h; and group III: euglycemic insulin (3 mU ⋅ kg-1 ⋅ min-1) clamp for ...

the devastating impact of land use change in the watershed is increasing the generation rate of sediment and entrance to rivers and sedimentation in reservoirs. according to this, studying on impact of land use change on hydrological process is necessary. aim of this study was investigating the impact of land use change on suspended sediment during 1994 to 2010 by swat model in dinevar watershe...

Cell-free protein synthesis has emerged as a powerful technology platform to help satisfy the growing demand for simple and efficient protein production. While used for decades as a foundational research tool for understanding transcription and translation, recent advances have made possible cost-effective microscale to manufacturing scale synthesis of complex proteins. Protein yields exceed gr...

The close anatomical relationships betaeen pancreatic alpha and beta cells makes possible their interaction at a local (paracrine) level. To demonstrate this in vivo, we have compared the acute glucagon response to intravenous arginine in the basal state and after beta cell suppression by infusions of insulin. The plasma glucose concentration was maintained by the glucose clamp technique. In si...

Mexico to monitor remotely the carbon monoxide (CO), hydrocarbons (HC) and nitric oxide (NO) emissions of the local vehicle fleet. In four days of monitoring at four different locations within the city, 26,534 vehicles passed the sensor. In all more than 24,000 valid measurements were obtained for CO, more than 23,000 for HC and more than 16,000 for NO. Mean values for each species were 1.69% C...

Pseudomonas putida CA-3 is capable of converting the aromatic hydrocarbon styrene, its metabolite phenylacetic acid, and glucose into polyhydroxyalkanoate (PHA) when a limiting concentration of nitrogen (as sodium ammonium phosphate) is supplied to the growth medium. PHA accumulation occurs to a low level when the nitrogen concentration drops below 26.8 mg/liter and increases rapidly once the n...

This study aimed to investigate the influence of increasing salinity concentrations on some indicators of energy consumption such as dissolved oxygen consumption, the consumed energy, as well as the levels of blood glucose in Carassius auratus (Goldfish), because of their direct relation with the metabolism rates when fish are exposed to exertion. Fish with an average weight of 37.5+2.5 g were ...