Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is involved in...

In this paper we provide a new insight of the previous work of Grosen and Jørgensen [2002]. More precisely, firstly, we investigate the impact of regulatory authorities’ rules on the fair value of company’s liabilities and assets. We study how to choose regulation intervention levels in order to control the shortfall probability of the issuing company. The fact that the regulation rule depends ...

Differences in haemostatic parameters have been reported among smokers and non-smokers. However the relationships of these parameters with other risk factors of cardiovascular diseases have not been fully determined in Nigerians. We therefore aimed at assessing the relationship between fibrinogen, factor VII (FVII), age, body mass indeks (BMI), systolic blood pressure (SBP) and diastolic blood ...

The contents of FC, somatic coliphages and F-specific bacteriophages were measured in the stabilization pond and stabilization reservoir system of the City of Arad (Israel) in order to determine the efficiency of the treatment process regarding the microorganisms removal. Monitoring was conducted close to one year. Physical and chemical parameters (temperature, pH, BOD5, COD, SS) were also anal...

The present study investigated the functional characteristics of task-sets that were never applied before and were formed only on the basis of instructions. We tested if such task-sets could elicit a task-rule congruency effect, which implies the automatic activation of responses in the context of another task. To this end, a novel procedure was developed that revealed instruction-based task-ru...

The classic Gibbard-Satterthwaite Theorem establishes that only dictatorial voting rules are strategy-proof; under any other voting rule, players have an incentive to lie about their true preferences. We consider a new approach for circumventing this result: we consider randomized voting rules that only approximate a deterministic voting rule and only are approximately strategy-proof. We show t...

BACKGROUND miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor in tongue squamous cell carcinoma. Studies have shown that miR-184 was down-regulated in glioma and TNFα-induced protein 2 (TNFAIP2) was closely related to tumorigenesis. This study aimed to determine the functions of miR-184 in glioma and the mechanisms of miRNA-184-TNFAIP2 mediated glioma prog...

BACKGROUND Diaphorina citri populations in Florida are developing resistance to commonly used neurotoxic insecticides. Alternatives to neurotoxins, such as insect growth regulators, are needed to control this season-long subtropical pest to prevent or delay development of insecticide resistance. In the present investigation, two insect growth regulators (IGRs), buprofezin and diflubenzuron, wer...

Human microRNA 184 (miR-184) is overexpressed in squamous cell carcinoma (SCC) of the tongue. In vitro inhibition of miR-184 levels could induce apoptosis and hinder proliferation of tongue SCC cells. Patients with tongue SCC have high plasma miR-184 levels. Plasma miR-184 is likely associated with the tumor load. Surgical removal of the primary tumor reduced plasma miR-184 levels significantly...

RATIONALE PKP2, encoding plakophilin 2 (PKP2), is the most common causal gene for arrhythmogenic cardiomyopathy. OBJECTIVE To characterize miRNA expression profile in PKP2-deficient cells. METHODS AND RESULTS Control and PKP2-knockdown HL-1 (HL-1(Pkp2-shRNA)) cells were screened for 750 miRNAs using low-density microfluidic panels. Fifty-nine miRNAs were differentially expressed. MiR-184 wa...