Although many components of the genetic pathways that provide positional information during embryogenesis have been identified, it remains unclear how these signals are integrated to specify discrete tissue territories. Here, we investigate the molecular mechanisms underlying the formation of one of the hindbrain segments, rhombomere (r) 3, specified by the expression of the gene krox20. Dissec...

Mononuclear leukocytes are able to destroy tumor cells under a variety of circumstances. In few such instances is the biochemical basis of cytotoxicity understood. Recently, we demonstra ted that activated macrophages, s t imulated by phorbol myristate acetate (PMA), 1 secreted substantial amounts o f hydrogen peroxide (1). The release o f this oxidant from macrophages correlated with the extra...

Human embryonic stem cells (hESCs) are routinely cultured on fibroblast feeder layers or in fibroblast-conditioned medium (CM). Bone morphogenetic proteins (BMPs) have previously been shown to induce hESC differentiation, in apparent contrast to mouse embryonic stem (ES) cells, in which BMP4 synergizes with leukemia inhibitory factor (LIF) to maintain self-renewal. Here we demonstrate that hESC...

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential in...

The rapid increase of paddy field acreage has led to widely descending of groundwater table in well irrigation paddy area of low-land in Sanjiang Plain recent years. More and more “hanging pump” and partial over pumping phenomenon have been occurring in well irrigation paddy area of low-land. Therefore, the groundwater resources in Sanjiang Plain need to be recharged urgently. For solving the m...

Subduction zones are the primary regions on Earth today where crust recycling takes place, and through geological time they have been the sites of continent formation. Many of the key elements (e.g., Th, rare earth elements, Ba, and Be) that are important in understanding crustal growth are sequestered in the sedimentary column and in the uppermost oxidized portions of the volcanic section of o...

An error in the interpretation of a reference paper by Hammad et al. [ Acta Cryst. (2018), E 74 , 853–856] is corrected.