An iconic, visionary giant in medical science, Alfred G. Knudson, Jr., M.D., Ph.D. died July 10, 2016, one month short of his 94 birthday. Often referred to as the ‘‘Mendel of cancer genetics’’—Al was widely known for his groundbreaking ‘‘two-hit’’ hypothesis of cancer development and his prediction of recessiveacting tumor suppressor genes. His revolutionary two-hit hypothesis envisaged that c...

23 8 0 31 Summary of the Madras statistics. (1) The number of gastric operations has increased from 8 in 1918 to 260 in 1926. (2) The total of all admissions for these ulcers has increased from 205 in 1922 to 422 in 1926. (3) There was a sudden increase in gastric operations from 12 in 1921 to 132 in 1922. (4) All duodenal ulcers are admitted to the surgical wards and two out of three undergo o...

Centrado nas discussões acerca do sistema literário nacional, proposto por Antonio Candido, e dos subsistemas regionais ou arquipélagos culturais, o presente estudo realiza-se, tendo em vista uma visão panorâmica da literatura produzida no Pará, sobretudo quando subsistema começa a se consolidar, ao redor de revistas suplementos literários, que participaram autores como Bruno Menezes (1893-1963...

, 1511 (2011); 334 Science Marvin Caruthers and Robert Wells 2011) − Har Gobind Khorana (1922 This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or ...

In this paper I estimate a SVAR model to study the transmission of UK shocks to the Irish economy over the period 1922-1979, using annual time series for CPI inflation and output growth. UK aggregate demand and supply shocks have large and significant impacts on Irish inflation, but smaller impacts on Irish real GDP growth. A historical decomposition indicates that UK aggregate demand shocks pl...

1. In the reception of light by the eye a common variable is the intensity of the illumination. Indeed, in order to analyse phenomena like dark adaptation and intensity discrimination it has been necessary to assume (Hecht, 1921-22, c; 1923-24, d) certain relations between the intensity of light and its action on the photosensitive material in the eye. The idea that visual purple is the sensiti...

During parasitological surveys of freshwater fish from the Miranda River, Brazil, 199 Pygocentrus nattereri Kner (Characidae) were caught. Two pentastomid families, Subtriquetridae Fain, 1961, represented by its single genus Subtriquetra Sambon, 1922, and Sebekidae Sambon, 1922, represented by three genera, were present. Free-living larvae of Subtriquetra subtriquetra (Diesing, 1835) were colle...

A new species of the genus Megalommum Szépligeti (Hymenoptera: Braconidae: Braconinae), reared from the pistachio longhorn beetle (Calchaenesthes pistacivora Holzschuh; Coleoptera: Cerambycidae), is described and illustrated. The genera Curreia Ashmead, 1900 and Endovipio Turner, 1922 are new synonyms of Megalommum Szépligeti, 1900. Notes on the biology of Megalommum pistacivoraesp. n. and a ke...