نتایج جستجو برای: 2 aminothiazole
تعداد نتایج: 2525278 فیلتر نتایج به سال:
Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, 2′-bromoacetophenones. The three-component preparation thioureas is followed by cyclization leading to heterocyclic product. This efficient mild procedure features excellent step- atom-economy enables chromatography-free diversely substituted 2-imin...
Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 clinical trials, SAP affects several aspects of the innate immune system to reduce fibrosis, whereas ...
Human rhinovirus (HRV) is the predominant cause of the common cold, but more importantly, infection may have serious repercussions in asthmatics and chronic obstructive pulmonary disorder (COPD) patients. A cell-based antiviral screen against HRV was performed with a subset of our proprietary compound collection, and an aminothiazole series with pan-HRV species and enteroviral activity was iden...
A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure composition of the obtained were proven NMR spectroscopy high-resolution mass spectrometry. cytotoxicities structurally similar palladium(II) complexes 2-aminothiazole tested against human cancer cells various histogenesis (MC...
The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity by designing and synthesizing a large number of analogs and testing these for activity against M. tuberculosis, as well as eukaryotic cells. We determined that the C-2 position of the thiazole can accommodate a range of lipophilic substi...
The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the signal amplification by reversible exchange (SABRE) process to cre...
A highly efficient, rapid and catalyst free protocol has been developed for the synthesis of 2-aminothiazoles in tetrahydrofuran (THF). Reaction was carried out at room temperature and the products were obtained in high yields without further purification.
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