background: several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (mscs) in allogeneic or mitogenic interactions. cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. objective: to investigate if adipose derived mscs could inhibit jurkat lym-phoblastic leukemia t cell proliferation during coculture. me...

age related cytochemical changes of thymic endocrine cells were studied in 78 day old chicks at five day interval to age of day 60 employing a panel of cytochemical stains. methenamine silver revealed cell morphology including cell processes distinctly while diamine silver revealed a stronger argentaffinity in these cells. the cells had greater affinity for diamine silver compared to methenamin...

background: umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell transplantation (hsct), used in leukemia treatment. cd26+ cells, a fraction of cd34 positive cells, are a major population of ucb cells which negatively regulate the in vivo homing and engraftment of hscs. cd26 is highly expressed in various cells such as hscs, immune cells, fibroblasts, and epithelial ce...

A series of arylketo-containing P1-P3 linked macrocyclic BACE-1 inhibitors were designed, synthesized, and compared with compounds with a previously known and extensively studied corresponding P2 isophthalamide moiety with the aim to improve on permeability whilst retaining the enzyme- and cell-based activities. Several inhibitors displayed substantial increases in Caco-2 cell-based permeabilit...

Introduction: Embryonic Stem (ES) cells as pluripotent cells derived from the inner cell mass of blastula can differentiate to neural cells in vitro and this property is valuable in studies of neurogenesis and in the generation of donor cells for transplantation. In this regard, the propose of this research, was the study of the role of two important factors in the development of neural syst...

Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...

introduction demyelination is a common lesion of spinal cord injury; cell therapy is an approach for replacing the lost oligodendrocytes. objective in this study, bone marrow stromal cells (bmscs) have been transdifferentiated into oligodendrocyte-like cells (olcs) and used in cytotherapy of contused spinal cords in rats. materials and methods the bmscs were collected from rat long bones, cultu...

the purpose of the present study is to investigate the prevalence of th17 and regulatory t (treg) cells in children with allergic rhinitis (ar) accompanying with bronchial asthma (ba).24 children with ar, 22 children with ba, 18 children with ar accompanying with ba,and 20 healthy controls were recruited. the prevalence of peripheral blood th17 and treg cells were determined by flow cytometry. ...

background: umbilical cord tissue is a very rich source of mesenchymal stem cells. instead of discarding this source we are banking the tissue along with cord blood for possible future cell based applications. the cord tissue needs to be transported and stored properly in order for it to be good enough for cell isolation at a later date. in this paper we have carried out a validation study to d...

background: despite the extensive information available in the literature, cell surface marker signature of human amniotic epithelial cells (haecs) remains controversial. the aim of the present study was to characterize immuno-phenotypic features, proliferative capacity and immunogenicity of haecs. we also tested whether expression of some cell surface markers is influenced by the type of tryps...