Chalcone derivatives (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one (Compounds 1 and 2) have been demonstrated to be potent anti-inflammatory agents in our previous study. In light of the relationship of intracellular mechanisms between anti-inflammatories and antioxidants, we further designed and synthesized...

BACKGROUND The present report describes the semi-synthesis of a few O-prenylated phenolic derivatives and their in vitro antitumor activities. These compounds were prepared by modifying two naturally occurring antitumor phenols, 5,7-dihydroxy-3-(1'-hydroxy-1'-phenyl-methyl)-6-methoxy-chroman-4-one (A) and 2',4'-dihydroxy-3',6'-dimethoxychalcone (B), previously isolated from Polygonum limbatum M...

In botany textbooks the farinose coating on leaves and inflorescences of many Primula species is still often said to "consist of flavone". We have shown earlier [1, 2] that it is in fact formed by varying amounts of unsubstituted flavone (at least 50%), 5-hydroxy flavone and 2'-hydroxy flavone, accompanied in many species by 5,8-dihydroxy flavone (primetin) and 5,2'-dihydroxyflavone. Further co...

OBJECTIVE(S) Chalcones and their rigid analogues represent an important class of small molecules having anticancer activities. Therefore, in this study the synthesis and cytotoxic activity of new 3-benzylidenchroman-4-ones were described as rigid chalcone analogues. MATERIALS AND METHODS The reaction of resorcinol with 3-chloropropionic acid in the presence of CF3SO3H was afforded correspondi...

The reaction of 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one with dimethyl acetylenedicarboxylate and benzil gave the respective 4H,6H-pyrano[3,2-g]chromene and imidazolylbenzopyran derivatives. Treatment of the imidazolylbenzopyran with hydrazine hydrate or hydroxylammonium chloride yielded imidazolylpyrazolylor imidazolylisoxazolylbenzenes, while the alkaline hydrolysis of imidazolyl...

BACKGROUND Type III polyketide synthases (PKSs) contribute to the synthesis of many economically important natural products, which are typically produced by direct extraction from plants or synthesized chemically. For example, humulone and lupulone (Fig. 1a) in hops (Humulus lupulus) account for the characteristic bitter taste of beer and display multiple pharmacological effects. 4-Hydroxy-6-me...

Caffeic acid/5-hydroxyferulic acid 3/5O -methyltransferase (COMT) is a small-molecule S -adenosylL -Met–dependent O -methyltransferase (OMT) that is one of the principal enzymes in the complex network of reactions that take place as part of lignin biosynthesis (Figure 1). Plants contain a wide variety of S -adenosylL -Met–dependent OMTs that act on Phe-derived substrates during the production o...

Objective: Tuberculosis (TB) is a major global issue, mainly owing to the emergence of antibiotic-resistant strains disease's causative agent, Mycobacterium tuberculosis. The current standard treatment for tuberculosis entails prolonged course antibiotics with toxic side effects and accompanied by low patient compliance. Therefore, developing discovering TB medications critical obtaining drugs ...

Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a controls homeostasis of glucose, and also improves insulin sensitivity. Therefore, the present study for the first time investigated the influence of tran...