objective: in this study investigated effects of different amounts of pelleted manure with urea and micro elements on yield and seed quality of medicinal plants, pumpkin (cucurbita pepo var. styriaca). methods: the animal manure and urea as pellet with four levels (150 kg urea, 50 kg urea + 3.5 ton animal manure, 100 (kg) urea+ 1.5 ton animal manure and 150 (kg) urea+1.5 ton animal manure) loca...

The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, ev...

The objective of this study was to evaluate the acute and subacute toxicity (28 days) of the ethanol extract of Z. zerumbet rhizomes (EEZZ) via the oral route in Wistar rats of both sexes. In the acute toxicity study, Wistar rats were administered a single dose of 15 g kg(-1) of body weight by gavage, and were monitored for 14 days. EEZZ did not produce any toxic signs or deaths; the 50% lethal...

It has been reported that ethanol enhances the hypnotic effect of gamma-hydroxybutyrate (GHB). In order to clarify the nature of this interaction we studied the pharmacokinetics and pharmacodynamics of combinations of GHB and ethanol in rats. Intraperitoneal injections of the GHB precursor gamma-butyrolactone (300 mg/kg) together with ethanol (3000 mg/kg) (n = 4) resulted in a longer "sleeping ...

OBJECTIVE Iron isomaltoside (Monofer(®)) is a high-dose intravenous iron preparation with good tolerability and efficacy in inflammatory bowel disease (IBD) patients with iron deficiency anaemia (IDA). This trial evaluates the safety and efficacy, including effect on intact fibroblast growth factor 23 (iFGF23) of a high single dose and cumulative doses of iron isomaltoside in IBD patients with ...

The aims of this study was to evaluate the acute and sub-acute toxicity Solanum aethiopicum Linn Gilo aqueous leaves extract in Wistar rats. Female rats received a single dose (2000, 3000, 4000 5000 mg/kg/ bw) for toxicity. Both, male female 300,500 800 bw during 21 days measurements. Blood sample collected determination some haematological, biochemical oxidative stress parameters. Besides, his...

Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier...

BACKGROUND Phase 2((R)) is a dietary supplement derived from the common white kidney bean (Phaseolus vulgaris). Phase 2 has been shown to inhibit alpha-amylase, the complex carbohydrate digesting enzyme, in vitro. The inhibition of alpha-amylase may result in the lowering of the effective Glycemic Index (GI) of certain foods. The objective of this study was to determine whether the addition of ...

abstract soil contamination with heavy metals is a serious problem in all over the world. soils are contaminated by many different sources of heavy metals. currently different methods are used by researchers for identifying heavy metal contamination. assessing soil metal toxicity with bacterial bioluminescence is one of the new techniques. in this study, different concentrations of zinc and cop...