Studying physics in spacetimes with dimensions less than four has often proved useful. While the study of such systems is of intrinsic interest, one usually has the hope that the properties of these lower-dimensional systems will mimic the properties of some corresponding four-dimensional system. Witten’s discovery @1# of a black hole solution in twodimensional string theory has sparked renewed...

Opioid addiction and pain can coexist at the end of life. Clinicians approved for schedule II prescribing by their DEA license can prescribe any schedule II drug in the inpatient and outpatient settings for pain and symptom relief, even if the patient is enrolled in an opioid maintenance program. Clinicians are strongly advised to seek specialist help in these situations (from both pain and add...

Osteosarcoma is the most common primary neoplasm of the bone and mainly occurs in adolescents and young adults. Despite great progress in current treatments, approximately one-third of patients with OS will not survive for more than five years, and fewer than 50% will live more than ten years. Aberrantly expressed microRNAs contribute to the carcinogenesis and progression of human cancers, incl...

1 Institute of Electronics, Technical University of Lodz Wolczanska St. 211/215 [email protected] 2 Institute of Electronics, Technical University of Lodz Wolczanska St. 211/215 [email protected] 3 Institute of Information Technology, Technical University of Lodz Wolczanska St. 211/215 [email protected] 4 Institute of Electronics, Technical University of Lodz Wolczanska St. 2...

Glioblastoma multiforme (GBM) is the most aggressive brain cancer, and to date, no curative treatment has been developed. In this study, we report that miR-211, a microRNA predicted to target MMP-9, is suppressed in grade IV GBM specimens. Furthermore, we found that miR-211 suppression in GBM involves aberrant methylation-mediated epigenetic silencing of the miR-211 promoter. Indeed, we observe...

Echinoderms are exclusively marine animals that, after the chordates, represent the second largest group of deuterostomes. Their diverse species composition and singular ecological niches provide at the same time challenges and rewards when studying the broad range of responses that make up their immune mechanisms. Two types of responses comprise the immune system of echinoderms: a cellular res...

Recent studies have shown that microRNAs play a pivotal role in the pathogenesis of cancer. In our current study, the expression levels of microRNA-211 (miR-211) were measured in human non-small-cell lung cancer (NSCLC) tissues and cell lines. We found that miR-211 expression levels were increased in NSCLC tissues and cell lines and that the overexpression of miR-211 promotes cell proliferation...

The adsorption and dissociation of CO over stepped Ni and Ni3Fe surfaces were systematically studied using density functional theory slab calculations. Both (211)-like surface structure terminations (NiNi step and NiFe step, denoted as Ni3Fe(211)-AA and Ni3Fe(211)-AB) are considered for Ni3Fe. Direct scission of the C-O bond in CO is identified as the least likely one among the three proposed d...