Wild-type p53 is well known to induce cell cycle arrest and apoptosis to block aberrant cell growth. However, p53's unique role in apoptosis and cell proliferation in Li-Fraumeni Syndrome (LFS) has not been well elucidated. The aim of this study is to characterize the activity of wild-type p53 protein in LFS family dominated by a germline negative mutant p53. As expected, etoposide-treated wild...

Web 2.0 is characterized by blogs, wikis, mashups and hundreds of websites supporting social exchanges including tagged bookmarks, pictures and personal profiles. This supports universal simple approaches to publication, composition of services and a rich metadata system for adorning URL's and people. The Semantic Grid has related goals but is typically implemented with tools and capabilities o...

Most of the efforts in elucidating the molecular relatedness and epidemiology of Staphylococcus aureus in Malaysia have been largely focused on methicillin-resistant S. aureus (MRSA). Therefore, here we report the draft genome sequence of the methicillin-susceptible Staphylococcus aureus (MSSA) with sequence type 1 (ST1), spa type t127 with Panton-Valentine Leukocidin (pvl) pathogenic determina...

Both the autonomous and chromosomally integrated F plasmids were found to replicate in a nonrandom fashion after a density transfer from heavy medium ([13C]glucose, 15NH4) to light medium ([12C]glucose, 14NH4). The data are consistent with the hypothesis that both the chromosome and the F plasmid are replicated in a cell cycle-specific manner. Thus, these data support the proposal (J. D. Keasli...

This paper concerns the effect of (separated/connected) protection zone for evolution an endangered species on reaction–diffusion equation with strong Allee and free boundary. First, we describe long-time dynamical behavior system two types zones same length. Furthermore, asymptotic profiles solutions spreading speed are estimated when happens. Our results, together those in previous papers Du ...

The purpose of this study was to investigate the relationship between bladder outlet obstruction (BOO) and the risk of being diagnosed with prostate cancer (PCa).Study population consisted of 2673 patients scheduled for the first prostate biopsy (PBx). All patients underwent uroflowmetry before PBx; those with a peak flow rate (PFR) <10 mL/s were considered to have BOO.The incidence of PCa was ...

Received 1/20/2004; revised 2/3/2004; accepted 2/5/2004. For correspondence or reprints contact: Feng-Yuan Liu, M.D., Department of Nuclear Medicine, Department of Nuclear Medicine, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kueishan, Taoyuan 333, Taiwan. Tel: (886)3-3281200 ext. 2673, Fax: (886)3-2110052, E-mail: [email protected] Fluorine-18 fluorodeoxyglucose positron emission tom...

In a literature review, the incidence and morbidity of bleeding complications after dental surgery in anticoagulated patients was compared with embolic complications when anticoagulation was interrupted. Over 99% of anticoagulated patients had no postoperative bleeding that required more than local hemostatic measures. Of more than 5431 patients undergoing more than 11,381 surgical procedures, ...