Objectives: The aim of the present study was to evaluate effects of various polymers on the release of a water soluble drug by using spray drying technique of microencapsulation. Methods: Spray drying is a single step technique, less time is required and loading efficiency is not affected by the nature of the drug whether hydrophilic or hydrophobic. Eudragit RS 30D, RL 30D and Ethylcellulose (S...

It is well established that male rats have an advantage in acquiring place-learning strategies, allowing them to learn spatial tasks more readily than female rats. However many of these differences have been examined solely during acquisition or in 24h memory retention. Here, we investigated whether sex differences exist in remote long-term memory, lasting 30d after training, and whether there ...

OBJECTIVE The aim of this study was to evaluate the expression levels of cardiac-related circulating microRNAs (miRNAs) in ST-elevation myo- cardial infarction (STEMI) patients. METHODS This study has a prospective experimental cohort design. A total of 12 consecutive patients with acute chest pain within 12 h admit- ted to emergency department (STEMI group) and 13 adult patients with normal ...

miR-30d is known to be up-regulated during the acquisition of receptivity in the endometrium. In order to determine the transcriptomic and proteomic changes which occur after transient overexpression of miR-30d in primary endometrial epithelial cells, in vitro cultured human endometrial epithelial cells (hEECs) were studied experimentally. Two different miRNAs (scramble versus mimic; n = 15) we...

Floating multi-layer coated tablets were designed based on gas formation. The system consists of a drug-containing core tablet coated with a protective layer (hydroxypropyl methylcellulose), a gas forming layer (sodium bicarbonate) and a gas-entrapped membrane, respectively. The mechanical properties of acrylic polymers (Eudragit RL 30D, RS 30D, NE 30D) and ethylcellulose were characterized by ...

Background. NK cells are imperative in spontaneous antitumor response of various cancers. Currently, lncRNAs considered important modulators the tumor microenvironment. This study investigated molecular mechanism by which mitotically associated long noncoding RNA (MANCR) controls killing effect on lung adenocarcinoma (LUAD) Methods. The interplay between MANCR and miRNA-30d-5p was analyzed bioi...

BACKGROUND MicroRNA (miRNA) expression is known to be deregulated in ovarian carcinomas. However, limited data is available about the miRNA expression pattern for the benign or borderline ovarian tumors as well as differential miRNA expression pattern associated with histological types, grades or clinical stages in ovarian carcinomas. We defined patterns of microRNA expression in tissues from n...

BACKGROUND AND AIMS Recent studies have shown that low molecular weight heparins are effective in the treatment of inflammatory bowel disease. Therefore, there is considerable interest in the development of an oral colonic delivery pharmaceutical system allowing targeted release of heparin in the inflamed tissue. The objective of this study was to prepare microparticles for the oral administrat...

In order to ascertain whether chemical alterations in cell surface glycopeptides may be associated with tumor progression, we isolated Sialoglycopeptide fractions from the surface of AS-30D rat ascites hepatoma cells before and after tumor progression. During the 70th to 90th transplantation generation of the AS-30D tumor, a morphological change and an increase in tumor virulence were observed....

The CO2-ratios method is applied to the analysis of abnormalities of TCA (tricarboxylic acid)-cycle metabolism in AS-30D rat ascites-hepatoma cells. This method utilizes steady-state 14CO2-production rates from pairs of tracers of the same compound to evaluate TCA-cycle flux patterns. Equations are presented that quantitatively convert CO2 ratios into estimates of probability of flux through TC...