=. Accessed Jan 1, 2000. 9. Lederberg J. Digital communications and the conduct of science: the new literacy. Proc IEEE. 1978;66(11):1314–9. 10. National Library of Medicine. Profiles in Science. NLM, 1999. Available at: http://www.profiles.nlm.nih.gov. Ac-

That the first half of the fourteenth century was a period of ecological and economic shocks is truism requires no argumentation. In England, as elsewhere in Northern Europe, the local population was hit by a series of harsh crises, the three most devastating of which were the Great Famine of 1314/5-22, the Great Cattle Plague of c.1315-21 and the Black Death of 1348-51. While the latter has be...

. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of January 8, 2010 ): The following resources related to this article are available online at www...

Ludwig der Bayer (1314 – 1347), Reich und Herrschaft im Wandel, hg. Auftrag des Arbeitskreises Stadtgeschichte München von Hubertus Seibert, Regensburg: Schnell & Steiner 2014. 543 S. ISBN 978-3-7954-2757-3. € 39,95

The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis through interaction with hepatic transporters. To date, a relatively strong association between dru...