نتایج جستجو برای: 342
تعداد نتایج: 4568 فیلتر نتایج به سال:
Background Insulin-like growth factor-1 receptor (IGF-1R) is a well-studied oncogenic factor that promotes cell proliferation and energy metabolism and is overexpressed in numerous cancers including hepatocellular carcinoma (HCC). Aerobic glycolysis is a hallmark of cancer, and drugs targeting its regulators, including IGF-1R, are being developed. However, the mechanisms of IGF-1R inhibition an...
BACKGROUND Long non-coding RNA (lncRNA) H19 has been reported to involve in many kinds of human cancers and functions as an oncogene. Our previous study found that H19 was over-expressed in gallbladder cancer (GBC) and was shown to promote tumor development in GBC. However, the competing endogenous RNA (ceRNA) regulatory network involving H19 in GBC progression has not been fully elucidated. We...
Notch signaling is critically involved in neural development, but the downstream effectors remain incompletely understood. In this study, we cultured neurospheres from Nestin-Cre-mediated conditional Rbp-j knockout (Rbp-j cKO) and control embryos and compared their miRNA expression profiles using microarray. Among differentially expressed miRNAs, miR-342-5p showed upregulated expression as Notc...
? Diese Arbeit entstand im Teilprojekt A6 des SFB 342 der Deutschen Forschungsge-meinschaft.
We present high spatial resolution (1.2′′) mm-interferometric observations of the 12CO(2− 1) line emission in the central 300 pc of the late-type spiral galaxy IC 342. The data, obtained with the Owens Valley Radio Observatory, allow firsttime detection of a molecular gas disk that coincides with the luminous young stellar cluster in the nucleus of IC 342. The nuclear CO disk has a diameter of ...
The direct instillation of radiolabelled conjugates in the urinary bladder is a promising path for the treatment of bladder carcinoma. The targeting of HER2/neu receptors expressed on the surface of many bladder carcinoma cells shows potential to be developed as a therapeutic strategy, and patients identified with a high risk of progression may benefit from adjuvant targeted radionuclide therap...
The causes of diarrhoea in people returning from travelling can be infective and non-infective, and the duration of symptoms is an important factor in identifying the cause. The article outlines the appropriate investigations Publication Details Zwar, N. A. & Torda, A. (2011). Investigation of diarrhoea in a traveller just returned from India. BMJ, 342 (7810), 342-1-342-5. This journal article ...
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