Herbein, Joel F., Jordan Savov, and Jo Rae Wright. Binding and uptake of surfactant protein D by freshly isolated rat alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 278: L830–L839, 2000.—Alveolar type II cells secrete, internalize, and recycle pulmonary surfactant, a lipid and protein complex that increases alveolar compliance and participates in pulmonary host defense. Surfactant p...

Grover, Theresa R., Robyn L. Rairigh, Jeanne P. Zenge, Steven H. Abman, and John P. Kinsella. Inhaled carbon monoxide does not cause pulmonary vasodilation in the late-gestation fetal lamb. Am J Physiol Lung Cell Mol Physiol 278: L779–L784, 2000.—As observed with nitric oxide (NO), carbon monoxide (CO) binds and may activate soluble guanylate cyclase and increase cGMP levels in smooth muscle ce...

We maximized mutual information between the sensor locations (treated as random variables) to find a near-optimal choice of k sensors. In the original paper, the authors used a gaussian process to model the random variables and they therefore had analytical expressions for the mutual informations. Given data X1, . . . , Xn ∈ R (we have p possible sensor locations and n samples), they fit a gaus...

Van Scott, Michael R., J. Paul Justice, John F. Bradfield, Edward Enright, Anastasia Sigounas, and Sanjiv Sur. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am J Physiol Lung Cell Mol Physiol 278: L667–L674, 2000.—We investigated the effects of interleukin (IL)-10 administration on allergen-induced Th2 cytokine production, eosinophilic i...

The uraemic syndrome is a complex mixture of organ dysfunctions attributed to the retention of a myriad of compounds that under normal conditions are excreted by healthy kidneys. While recent years have seen major steps in the identification and characterisation of uraemic retention solutes and in the knowledge of their patho-physiological importance, this knowledge remains far from complete. T...

SEKIYA KOYAMA,1,2 ETSURO SATO,2 HIROSHI NOMURA,2 KEISHI KUBO,2 MASAKAZU MIURA,3 TETSUJI YAMASHITA,3 SONOKO NAGAI,4 AND TAKATERU IZUMI4 1National Chuushin Matsumoto Hospital, Matsumoto 399; 2The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390; 3Mitsubishi Kagaku, Itabashiku, Tokyo 174; and 4Department of Respiratory Medicine, Graduate School of Medicin...

GEERT A. BRAEMS,1–3 LI-JUAN YAO,1,2,4 KEVIN INCHLEY,1,2,4 ANNE BRICKENDEN,1,2,4,5 VICTOR K. M. HAN,1–6 ALLEN GROLLA,1,2 JOHN R. G. CHALLIS,2,3,7 AND FRED POSSMAYER1–5 Departments of 1Obstetrics and Gynaecology, 5Biochemistry, and 6Pediatrics, 2Medical Research Council Group in Fetal and Neonatal Health and Development, 3Lawson Research Institute, and 4London Health Sciences Centre, University o...

Elena Tchekneva, Mayme L. Lawrence, and Barbara Meyrick. Cell-specific differences in ET-1 system in adjacent layers of main pulmonary artery. A new source of ET-1. Am J Physiol Lung Cell Mol Physiol 278: L813–L821, 2000.— Endothelin-1 (ET-1) is a potent vasoconstrictor that causes sustained constriction of the pulmonary artery and modulates normal vascular tone. Endothelial cells were thought ...

Cereal storage proteins are major nitrogen sources for humans and livestock. Prolamins are the most abundant storage protein in most cereals. They are deposited into protein bodies (PBs) in seed endosperm. The inner structure and the storage mechanism for prolamin PBs is poorly understood. Maize opaque10 (o10) is a classic opaque endosperm mutant with misshapen PBs. Through positional cloning, ...