Aerobic organisms have a tricarboxylic acid (TCA) cycle that is functionally distinct from those found in anaerobic organisms. Previous reports indicate that the aerobic pathogen Mycobacterium tuberculosis lacks detectable alpha-ketoglutarate (KG) dehydrogenase activity and drives a variant TCA cycle in which succinyl-CoA is replaced by succinic semialdehyde. Here, we show that M. tuberculosis ...

We earlier reported that the soluble form of the CD40 ligand (sCD40L), is involved in thrombosis by stabilizing platelet thrombi. In this article, we have determined the mechanism by which this protein affects platelet biology. Addition of sCD40L to washed platelets was found to activate the receptor function of alphaIIbbeta3 as measured by the induction of fibrinogen binding and the formation ...

For scalability purposes, multiple physical resources that interconnect Label Switching Routers (LSRs) can be combined to form a single traffic engineering (TE) link for the purposes of path computation and signaling. These resources may represent one or more physical links that connect the LSRs, or they may represent a Label Switched Path (LSP) if LSP hierarchy [RFC4206] is used. The managemen...

Cell-Selective Spider Silk Proteins In article number 2202660, Vanessa Tanja Trossmann and Thomas Scheibel design recombinant spider silk proteins to guide cell-specific materials interactions. The fusion of with short peptides from extracellular matrix such as KGD yield cell type selective binding, which enables the development hierarchically organized tissues.

The maximum present of protein was recorded PUSA-256(24.67) at par by KGD – 1168, Pant G-186, Kw-168 having 24.32, 23.42, and 23.67 percent respectively. infected grain Callosobruchus maculatus minimum KPG-59 (21.06) PUSA 256 (25.07) percent. fresh found PUSA-256 (24.67) KPG-59(21.06).

By exciting at 940 nm, we have characterized the 1.84 m near infrared emission of trivalent thulium ions in Yb3+, Tm3+:KGd WO4 2 single crystals as a function of the dopant concentration and temperature, from 10 K to room temperature. An overall H6 Stark splitting of 470 cm −1 for the Tm3+ ions in the Yb3+, Tm3+:KGd WO4 2 was obtained. We also studied the blue emission at 476 nm Tm3+ and the ne...

BACKGROUND: While the ability of bacteriophages to kill bacteria is well known and has been used in some centers to combat antibiotics - resistant infections, our knowledge about phage interactions with mammalian cells is very limited and phages have been believed to have no intrinsic tropism for those cells. PRESENTATION OF THE HYPOTHESIS: At least some phages (e.g., T4 coliphage) express Lys-...

Macrodefect-free single crystals of Yb-doped KGd(PO(3)), a noncentrosymmetric laser host which possesses second-order nonlinear susceptibility, were grown using the top seeded solution growth slow-cooling (TSSG-SC) technique, reaching a maximum ytterbium concentration in the crystal of approximately 3.2x10(20) at/cm(3). In order to evaluate the potential for self-frequency doubling, the dispers...

1589 Introduction Inflammation is often considered a contributing factor to thrombotic and hemostatic disorders associated with various disease states. These diseases include the coagulopathy of septicemia (1), the prothrombotic state associated with atherosclerotic vessels (2) or cancer (3), and the veno-occlusive disease of the liver after bone marrow transplantation (4). Previous studies hav...