نتایج جستجو برای: 432 سال
تعداد نتایج: 162138 فیلتر نتایج به سال:
• Spaces can be constructed by gluing simple things together. We constructed projective spaces, Klein bottles, and lens spaces that way. The simple pieces live in Rn, but the new objects usually don’t. (To be more precise, it is irrelevant and distracting to find an embedding of the new objects into Rn.) We introduced topological spaces and particularly the quotient topology so we could talk ab...
BACKGROUND The streptococcal agent OK-432 has been used for immunotherapy of head and neck cancer, among other malignancies, but its mechanism of action is unknown. Because the Toll-like receptor 4 (TLR4)/MD-2 complex is important in enabling the mammalian immune system to recognize bacterial components, we investigated whether expression of the TLR4 and MD-2 genes is associated with OK-432-ind...
Two altered GrlB proteins (one with an Asp-432-->Asn alteration and one with an Asn-470-->Asp alteration) of Staphylococcus aureus were purified as fusion proteins to maltose-binding protein. The 50% inhibitory concentrations of levofloxacin were 14 and 3.4 microg/ml against topoisomerase IV containing GrlB proteins with alterations at positions 432 and 470, respectively. These results suggest ...
Immunotherapeutic response to concanavalin A (Con A)-bound L1210 murine leukemic vaccine and immunopotentiators was examined in histocompatible animals bearing a small burden L1210 leukemic cells. When combined with Con A-bound vaccine, a streptococcal immunopotentiator, OK-432 (NSC B116209), prepared from Streptococcus pyogenes, was potent in antitumor therapy and resulted in a number of cured...
هدف: هدف از پژوهش حاضر، شناسایی مؤلفههای آزردگیهای روانی انتقالیافته والدین به فرزندان، مبتنی بر مرور زندگی بود. روش: حاضر لحاظ روششناسی نوع کیفی و روش نظریه داده بنیاد و طریق نمونهگیری هدفمند نظری صورت گرفته است. جامعة موردپژوهش بین (پدر یا مادر) 35 تا 50 سال دارای فرزند نوجوان (دختر پسر در بازة سنی 13 18 سال) شهر تهران انتخاب شدند که بهصورت داوطلبانه مصاحبه حضور پیدا کردند. با استفاده ...
Sustained cell growth and proliferation, one of the hallmarks of cancer, is considered to responsible for cancer-related deaths by disorganizing the balance of growth promotion and growth limitation. Aberrant activation of the Wnt/β-catenin signaling pathway leads to cell proliferation, growth and survival, and promotes the development of various human tumors, including hepatocellular carcinoma...
Lymphangiomas are rare benign congenital tumours, involving both the head and the neck and causing obstructing symptoms in the upper airways as well as aesthetic anomalies. In recent years, sclerosing therapy with OK-432 has become the treatment of choice in the management of these lymphatic malformations. Nonetheless, surgery still seems to be the therapy advocated for resolution of symptoms. ...
INTRODUCTION SEP-432 is a triple monoamine reuptake inhibitor of norepinephrine (NE), serotonin (5-HT), and dopamine (DA), based on in vitro binding studies. We sought evidence that SEP-432 engages these monoamine systems by measuring concentrations of monoamines and/or their main metabolites in cerebrospinal fluid (CSF) and plasma and comparing results to duloxetine, a dual reuptake inhibitor ...
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