This paper intends to describe the demand for referrals stomatology service requested by medical teams inpatients in a reference hospital south of Brazil. research is retrospective cross-sectional descriptive study focusing on data collection and assessment information about unit carried out from January 2008 December 2018. All was obtained management software database, then transferred analyze...

Purpose:Docetaxel is extensivelymetabolized byCYP3A4 in the liver butmechanisms bywhich the drug is taken up into hepatocytes remain poorly understood.We hypothesized that (i) liver uptake of docetaxel is mediated by the polymorphic solute carriers OATP1B1 and OATP1B3 and (ii) inherited genetic defects in this process may impair systemic drug elimination. Experimental Design: Transport of docet...

Replication factor C (RF-C) is a heteropentameric protein essential for DNA replication and repair. It is a molecular matchmaker required for loading of proliferating cell nuclear antigen (PCNA) onto double-stranded DNA and, thus, for PCNA-dependent DNA elongation by DNA polymerases delta and epsilon. To elucidate the mode of RF-C binding to the PCNA clamp, modified forms of human PCNA were use...

Socioeconomic status (SES) discrepancies exist for child and adult cancer morbidity and are a major public health concern. In this Swiss population-based matched case-control study on the etiology of childhood leukemia, we selected the cases from the Swiss Childhood Cancer Registry diagnosed since 1991 and the controls randomly from census. We assigned eight controls per case from the 1990 and ...

Background: Healthy teeth and oral tissues and the need for oral health care are important for any section of society. Dental caries, the product of man's progress towards civilization, has a very high morbidity potential and thus, is coming into focus of the mankind. The prevalence and incidence of dental caries in a population is influenced by a number of risk factor such as sex, age, socioec...

The and proteins of the DNA polymerase III holoenzyme DnaX complex are products of the dnaX gene with being a truncated version of arising from ribosomal frameshifting. is comprised of five structural domains, the first three of which are shared by (Gao, D., and McHenry, C. (2001) J. Biol. Chem. 276, 4433– 4453). In the absence of the other holoenzyme subunits, DnaX exists as a tetramer. Associ...

BACKGROUND Prisons are important settings for blood-borne virus control because of the high prevalence of hepatitis C and B viral infections (HCV and HBV), and behaviours associated with transmission among prisoners. METHODS Data from sentinel laboratories in England were used to identify testing for hepatitis C (anti-HCV) and hepatitis B [hepatitis B surface antigen (HBsAg) and anti-hepatiti...

BACKGROUND We compared video-assisted thoracoscopic surgery (VATS) lobectomy and stereotactic body radiation therapy (SABR) to explore clinical outcomes in the treatment of patients with early stage NSCLC. METHODS Major medical databases were systematically searched to identify studies on VATS and SBRT published between January 2010 and October 2015. English publications of stage I and II NSC...

This paper describes a component model, called SISARL model. It is the basis of component-based approach to building families of smart devices and systems that enhance life quality and well being of elderly individuals. In addition to providing the traditional view of hardware, firmware and software components, as do existing component models, SISARL model also provides developers with an opera...