Takuya Ohno Department of Electrical and Computer Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466-8555 Japan Gaku Arakawa Department of Applied Physics, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466-8555 Japan Ikuo Ichinose Department of Applied Physics, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, 4...

Tooth root formation is initiated by the elongation of Hertwig’s epithelial root sheath (HERS). HERS cells are widely accepted to control root formation, but the mechanisms regulating HERS growth have not been elucidated. To solve this problem, we have established a new culture method for postnatal mouse mandibular molars and, using it, examined the role of insulin-like growth factor-I (IGF-I) ...

Editorial Franciscanum 177

Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical properties of AMPA receptors (AMPARs). Small-conductance Ca21-activated K1 channels (SK2 channels) are functionally coupled with NMDA receptors (NMDARs) in CA1 spines such that their activity modulates the shape of excitatory postsynaptic potenti...

Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells enriched in proteins that regulate actin polymerization. The on-off regulatory switch that initiates actin polymerization in invadopodia requires phosphorylation of tyrosine residues 421, 466, and 482 on cortactin. However, it is unknown which of these cortactin tyrosine phosphorylation sites control actin polymer...

Introduction: Bone pain palliation therapy is a mandate in handling end-stage cancer patients. The development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and GI) is still ongoing. Methods: In this work Lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177Lu-pamidronate; 177Lu-PAM ), ...