Benzodiazepines possess a wide spectrum of valuable pharmacological effects and are among the leading drugs, commonly prescribed ones for various pathologies. Herein we describe continuous flow synthesis six benzodiazepines from aminobenzophenones: diazepam, fludiazepam, nordazepam, nitrazepam, clonazepam, oxazepam.

In a recent publication, the authors reported a liquid chromatography-mass spectrometry-time of flight procedure for the simultaneous analysis of 22 benzodiazepines in urine specimens. In this report, the list of benzodiazepines that could be analyzed was expanded to 35 benzodiazepines, and data for the additional 13 analytes are presented. The analysis focused on the most commonly prescribed b...

Abstract Background The misuse of illicit substances is associated with increased morbidity and mortality; thus, substance abuse a global health concern. Arabian Gulf region considered crossing point consumer drugs. However, lack laboratory-based research has limited the scientific assessment drug in region. Thus, an up-to-date analytical representation situation warranted. Methods We investiga...

Introduction: In Singapore, non-anaesthesiologists generally administer sedation during gastrointestinal endoscopy. The drugs used for in hospital endoscopy centres now include propofol addition to benzodiazepines and opiates. requirements peri-procedural monitoring discharge protocols have also evolved. There is a need develop an evidence-based clinical guideline on the safe effective use of b...

BACKGROUND Often, long-term treatment with benzodiazepines is a subject of discussion due to potential side effects, with dependence on benzodiazepines as the most serous one. After longer period of benzodiazepines tolerance on their anxiolytic effects develops. Discontinuation is usually beneficial as it is followed by improved psychomotor and cognitive functioning, particularly in the elderly...

Benzodiazepines are widely prescribed drugs used to treat anxiety and insomnia, induce muscle relaxation, control epileptic seizures, promote anaesthesia or produce amnesia. Benzodiazepines are also abused for recreational purposes and the number of benzodiazepine abusers is unfortunately increasing. Within weeks of chronic use, tolerance to the pharmacological effects can develop and withdrawa...

From an historical standpoint, the development of our understanding of basic mechanisms of the actions of gamma aminobutyric acid (GABA) and benzodiazepines began on separate paths. Classical pharmacology revealed similarity between the actions of GABA and benzodiazepines in the central nervous system. Furthermore, pharmacological experiments with selective agonists and antagonists indicated th...

Objective: Benzodiazepines are a widely used class of medications for anxiety, depression, and insomnia. Despite their common use, concerns remain about memory problems with benzodiazepines. the growing financial social burden dementia, inconsistent results persist regarding association between benzodiazepines dementia. Therefore, we aimed to evaluate dementia in Korea. Methods: Diagnostic pres...