Two Bacillus subtilis genes encoding two proteins (currently annotated ThiD and YjbV) were overexpressed and characterized. YjbV has 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase activity and should be reannotated ThiD, and B. subtilis ThiD has pyridoxine, pyridoxal, and pyridoxamine kinase activity and should be reannotated PdxK.

Aryltellurium trichlorides have proven themselves as good cyclizing reagents in electrophilic intramolecular cyclization reactions, mainly of propenyl derivatives heterocycles. On the other hand, information on use butenyl reactions with p-alkoxyphenyltellurtrichlorides is limited. In this work, regioselectivity process but-2-enyl thioethers quinoline-3carbaldehyde and quinazolin-4-one p-methox...

Although a number of antiviral drugs inhibit replication of Epstein-Barr virus (EBV) in cell culture, and acyclovir (ACV) suppresses replication in vivo, currently available drugs have not proven effective for treatment of EBV-associated diseases other than oral hairy leukoplakia. Benzimidazole riboside compounds represent a new class of antiviral compounds that are potent inhibitors of human c...

Synthesis and preliminary biological evaluation of imidazo (2, 1-b) Thiazole derivatives is reported. Under Mannich conditions, a series new were synthesized. Starting from the reaction 2- amino thiazole with 4- bromo phenyl bromide to produce 5-(4-bromo phenyl) thiazoles, following by introduce substituted aminomethyl at position 6-by reacting different aromatic amines under conditions afford ...

The Sn atom in the title substituted pyridinium stannate bromo-3,4-dichloro-benzene solvate, (C(7)H(11)N(2))(2)[SnBr(4)(C(6)H(3)Cl(2))(2)]·C(6)H(3)BrCl(2), lies on a twofold axis within an octa-hedral C(2)Br(4) donor set. Each cation forms an N-H⋯Br hydrogen bond to one of the Br atoms of the anion. The solvent mol-ecule is disordered about the twofold rotation axis with equal occupancy. The cr...