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Annually, ovarian cancer (OC) affects 240,000 women worldwide and is the most lethal gynecological malignancy. High-grade serous OC (HGSOC) is the most common and aggressive OC subtype, characterized by widespread genome changes and chromosomal instability and is consequently poorly responsive to chemotherapy treatment. The objective of this study was to investigate the role of the microRNA miR...
This review aims to assess the efficacy and safety of voluntary fortification as an option to address the occurrence of inadequate micronutrient intakes in population subgroups in Europe. Although legislation is harmonised across the European Union, fortification practices and patterns of consumption of fortified foods vary considerably between countries. While the proportion of children consum...
MicroRNAs (miRNAs) are reported to have important roles in regulating the progression of numerous human cancers, although little is known regarding the role of miRNAs in colorectal cancer. The present study aimed to investigate the role of microRNA-433 (miR-433) in colorectal cancer. The expression levels of miR-433 and its target gene metastasis associated in colon cancer-1 (MACC1) in colorect...
DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3' untranslated region (3' UTR) was linked to PD-risk through a mechanism that would implicate a differential binding to microRNA-433 (miR-433). The reduction of the affinity of miR-433 to the 3' UTR would result in increased FGF20 expression and upregulation of alpha-synuclei...
9 〈35, 9, 2, 1〉 〈3, 50, 56, 1〉 〈10, 52, 34, 2〉 〈31, 44, 29, 0〉 〈37, 49, 17, 2〉 〈40, 39, 13, 0〉 〈1, 15, 53, 0〉 〈36, 7, 30, 2〉 〈11, 52, 48, 0〉 〈32, 43, 33, 2〉 〈38, 28, 56, 2〉 〈41, 36, 11, 1〉 〈12, 24, 9, 2〉 〈41, 1, 22, 2〉 〈23, 26, 35, 2〉 〈32, 55, 15, 1〉 〈38, 36, 54, 0〉 〈49, 35, 43, 0〉 〈28, 37, 2, 0〉 〈41, 6, 27, 0〉 〈26, 47, 18, 0〉 〈33, 20, 13, 1〉 〈40, 37, 42, 1〉 〈51, 24, 43, 1〉 〈29, 28, 6, 1〉 〈48, ...
YAP1 is an oncogene in plenty types of tumors and miR-433 is a tumor suppressor in many types of tumors. Furthermore, YAP1 is overexpressed in glioma and the function mechanism is still not entirely clear. So this study was aimed to investigate whether YAP1 expression in glioma is associated with miRNA. The YAP1 expression in glioma tissues and glioma cells and miR-433 expression in glioma tiss...
Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
MicroRNAs (miRNAs, miRs) are genomically encoded small approximately 22 nt RNA molecules that have been shown to mediate translational repression of target mRNAs involved in cellular proliferation, differentiation and death. Despite intensive studies on their physiological and pathological functions, the molecular mechanism of how miRNA gene transcription is regulated remains largely unknown. M...
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