Laryngeal squamous cell carcinoma (LSCC), the most common form of laryngeal carcinoma, is an aggressive malignancy that demonstrates the second highest rate of morbidity of all head and neck squamous cell carcinomas. The abnormal expression of microRNAs (miRs) has been demonstrated in a number of types of human cancer, and they have been demonstrated to be oncogenes or tumour suppressor genes. ...

The present study aimed to investigate the expression levels of microRNA (miR)‑503 in osteosarcoma (OS), as well as to assess the effects and underlying mechanisms of miR‑503 on cell proliferation, apoptosis, migration and invasion of OS cells. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to determine the expression levels of miR‑503 in OS and adjacent normal ...

sludge production is an avoidable problem arising from the treatment of wastewater. the sludge remained after municipal wastewater treatment contains considerable amounts of various contaminants and if is not properly handled and disposed, it may produce extensive health hazards. on the other hand, this sludge has benefits for plants and soils. thereupon, land application of sludge has received...

The development of multidrug-resistance (MDR) is a major contributor to death in colorectal carcinoma (CRC). Here, we investigated the possible role of microRNA (miR)-503-5p in drug resistant CRC cells. Unbiased microRNA array screening revealed that miR-503-5p is up-regulated in two oxaliplatin (OXA)-resistant CRC cell lines. Overexpression of miR-503-5p conferred resistance to OXA-induced apo...

Infectious diseases caused by soil-transmitted helminths (STHs) are important diseases of humans, which affect about one third of the world’s population. Examination of soil can be used to estimate the risk of STH infection in humans. We carried out this survey to clarify the current status of soil contamination by parasite eggs and to assess the risk of STH infection. During survey periods, we...

Epithelial-to-mesenchymal transition (EMT) is believed to be associated with cancer cell malignancy, and also to cause cancer invasion and metastasis. Recent evidence indicates that small non-protein coding RNA [microRNAs (miRNAs/miRs)] may act as powerful regulators of EMT. The present study aimed to systematically delineate miR-503 expression in gastric cancer and analyse the function of miR-...

MicroRNAs (miRs) have been demonstrated to play key roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-503 in HCC has not been fully uncovered. In this study, we found that miR-503 was significantly downregulated in HCC tissues compared to nontumorous liver tissues. Moreover, lower miR-503 levels were associated with the malignan...

The Dade Behring BCS is a coagulation analyser with optical reaction detection (standard 405 nm). The present study was conducted to evaluate measurement at 570 nm for analyses in interfering plasma samples. Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and D-dimer in normal (n=50), lipaemic (n=60), icteric (n=113), and haemolytic (n=58) samples were measured a...

Loss of pancreatic β cells is involved in pathogenesis of gestational diabetes mellitus (GDM). Recently, several studies have elucidated the connection between microRNAs (miRNAs) and diabetes mellitus (DM), but the role of miRNAs in GDM remains unclear. The aim of this study was to evaluate the potential functions of miRNAs in GDM and to investigate the underlying mechanisms of action. First, w...

Gene L Bowman1† & Joseph F Quinn2 †Author for correspondence 1Oregon Health & Science University, CR-131 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: [email protected] 2Oregon Health & Science University, Clinical Core, NIA-Layton Aging & Alzheimer’s Disease Center, OR, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: qu...