The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably, some of these receptors recognize components of our own body, and so cellular mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve immunological self tolerance. Many of the genes and proteins involved a...

Diet is a major factor in the aetiology of colorectal cancer (CRC). Epidemiological evidence suggests that folate confers a modest protection against CRC risk. However, the relationship is complex, and evidence from human intervention trials and animal studies suggests that a highdose of folic acid supplementation may enhance the risk of colorectal carcinogenesis in certain circumstances. The m...

The investment decisions of small-scale farmers in developing countries are conditioned by their financial environment. Binding credit market constraints and incomplete insurance can limit investment in activities with high expected profits. We conducted several experiments in northern Ghana in which farmers were randomly assigned to receive cash grants, grants of or opportunities to purchase r...

In archived samples from the German environmental specimen bank (ESB) organotin compounds including tributyltin (TBT) and triphenyltin (TPT) as well as their potential degradation products were quantified. Muscles of bream (Abramis brama) sampled in the period 1993-2003 from the rivers Rhine, Elbe, Saale, Mulde, Saar, and from Lake Belau (period 1988-2003) were analyzed by gas chromatography/at...

1 C3NL, Centre for Restorative Neuroscience, Division of Brain Sciences, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK 2 Systems and Restorative Neurology, University of Cambridge Neurology Unit, Herchel Smith Building for Brain and Mind Sciences, Robinson Way, Cambridge, CB2 0SZ, UK 3 Institute of Cognitive Neuroscience, Univers...

Historically, economic changes have negatively affected the nursing workforce in Ontario. The trend towards part-time and casual employment emerged from healthcare restructuring in the 1990s. The severe acute respiratory syndrome (SARS) outbreak in 2003 alerted the Ontario government to the issue of part-time and casual nursing. In 2007, the Nursing Graduate Guarantee (NGG), a health human reso...

In this first lecture, we begin by introducing the Chinese Restaurant Process. After a brief review of finite mixture models, we describe the Chinese Restaurant Process mixture, where the latent variables are distributed according to a Chinese Restaurant Process. We end by noting a connection between Dirchlet processes and the Chinese Restaurant Process mixture. We will define a distribution on...

Wide distribution of chlorinated paraffins in the environment has already been demonstrated in several studies; however, information about their levels in the Central Europe is still very limited. First study focused on the SCCP contamination of the Czech aquatic environment have been performed recently, and its results motivated the authors to analyze sediments from a wide set of the Czech riv...

The GridTrust Security Framework (GSF) offers security and trust management for the next generation Grids (NGG). It follows a vertical approach for Grid security from requirements level right down to application and middleware levels. New access control models for collaborative computing, such as the usage control model (UCON), are implemented for securing the Grid systems. The GSF is composed ...