Gemcitabine has been the standard chemotherapy for advanced pancreatic cancer since 1997, when a randomized phase III study demonstrated that gemcitabine significantly improved cancer-related symptoms in comparison with 5-fluorouracil (5-FU) (Burris et al., 1997). However, the survival benefit of gemcitabine is modest and the median survival time was 5.7 and 4.4 months for gemcitabine and 5-FU ...

We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...

The serendipitous discovery by Rosenberg et al. [ 1 ] that cell replication could be inhibited by platinum complexes led to the development and therapeutic use of cisplatin (cis-diamminedichloroplatinum II) as an anticancer agent. Cisplatin is currently used in treating testicular, ovarian, and lung cancers as well as squamous cancers of the head and neck [ 2-51. The anticancer agent 5fluoroura...

Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed–Sternberg cells. Adenocarcinoma is the most frequent pathological type of stomach cancer. Improved survival in HL patients leads to the development of secondary malignancies. However, synchronous occurrence of these 2 malignancies is extremely rare. Here, we present a 45-year-ol...

Capecitabine is a chemotherapeutic agent of the fluoropyrimidine family, indicated in metastatic colorectal cancer and advanced breast cancer. Its main cutaneous adverse effect is hand-foot syndrome (HFS); cases of skin hyperpigmentation, nail changes, and alterations of the mucosas secondary to this drug have also been reported. Capecitabine is converted to 5-fluorouracil by the enzyme thymidi...

The aim of this study was to analyze the clinical efficacy, prognosis, and risk factors of surgery combined with chemotherapy in treating Hepatoblastoma (HB). A total of 102 HB patients diagnosed and enrolled in Beijing Tongren Hospital from September 2006 to June 2014 were included in this study. Clinical stage of HB was determined according to the Post-surgical staging system of the Children ...

5-Fluorouracil is reported as the second most common chemotherapeutic agent after anthracyclines causing cardiotoxicity. Thirty male albino rats were divided into three groups. Rats in group I received saline daily for 8 days only and served as the control. Rats in group II received saline orally for 8 days, then administrated with 5-Fluorouracil (150mg\ kg B.W\once I.P injection at the 5 day)....