AIM To evaluate the visual outcomes of simultaneous non-topography guided photorefractive keratectomy (PRK) and corneal collagen cross-linking (CXL) in eyes with keratoconus 5y after the procedure. METHODS Prospective, interventional, non-randomized, and non-controlled case series design was used. Sixty eyes of 30 patients (16 males and 14 females; age: 21-41y) with mild, non-progressive (sta...

Purpose: To investigate fatigue damage over time, monolithic posterior computer-aided-designed/computer-aided-manufactured (CAD/CAM) crowns were artificially aged in a mouth-motion-simulator, and was monitored with optical coherence tomography (OCT). Methods: Forty-eight milled of six different CAD/CAM-materials (n=8), including 3Y-TZP (Lava Plus,‘3Y’), 4Y-PSZ (Pritidentamultidisc,‘4Y’), 5Y-PSZ...

Hyperphosphorylation of the microtubule-associated tau proteins is one of the main pathological events that leads to neurofibrillary neurodegeneration in Alzheimer's disease. A similar tau phosphorylation pattern may be obtained in SY-5Y neuroblastoma cells after okadaic acid treatment. In this paper, we clearly demonstrate phosphorylation of Ser422 in tau proteins of treated cells as well as i...

The translocator protein of 18kDa (TSPO) is located in the outer mitochondrial membrane and is involved in the cholesterol transport into the mitochondria and in the regulation of steroidogenesis, mitochondrial permeability transition pore opening and apoptosis. TSPO ligands have been investigated as therapeutic agents that promote neuroprotective effects in experimental models of brain injury ...

Phosphorylation is the major post-translational modification of Tau proteins and it plays an important role in Tau biological functions. Hyperphosphorylation of these proteins occurs during neurodegenerative disorders such as Alzheimer's disease. It was hypothesized that some variants of apolipoprotein E (apo E) may have a protective effect against the normal or pathological phosphorylation of ...

Accumulation of amyloid beta and its toxicity are the common features in Alzheimer’s disease. Autophagy plays an important role development progression disease by causing selfdegradation accumulated from neurons. Glycitin has been found as major phytochemical constituent soybean, which shows neuroprotective function The present study aims to explore glycitin clearance reducing neuronal cells. h...

BACKGROUND The androgen receptor (AR) expression and the CAG repeat length within the AR gene appear to be involved in the carcinogenesis of male breast carcinoma (MBC). Although phenotypic differences have been observed between MBC and normal control group in AR gene, there is lack of correlation analysis between AR expression and CAG repeat length in MBC. The purpose of the study was to inves...

BACKGROUND In April 2015, Kamwenge District, western Uganda reported a measles outbreak. We investigated the outbreak to identify potential exposures that facilitated measles transmission, assess vaccine effectiveness (VE) and vaccination coverage (VC), and recommend prevention and control measures. METHODS For this investigation, a probable case was defined as onset of fever and generalized ...