Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system mediated by autoimmune and neurodegenerative pathogenic mechanisms. Multiple genes account for its moderate heritability, but the only genetic region shown to have a large replicable effect on MS susceptibility is the major histocompatibility complex (MHC). Strong linkage disequilibrium (LD) across the MHC h...

Mobile phones are becoming important instruments for assessing diet and energy intake. We developed the Tool for Energy Balance in Children (TECH), which uses a mobile phone to assess energy and food intake in pre-school children. The aims of this study were: (a) to compare energy intake (EI) using TECH with total energy expenditure (TEE) measured via doubly labelled water (DLW); and (b) to com...

Spectral optimization for naturalness and preference was carried out empirically in a set of psychophysical experiments in which observers adjusted the spectral composition of the illumination to render commercial food counters containing a variety of fruits and vegetables as well as meat and fish. The scenes were simulated with high chromatic precision on a calibrated computer monitor from dat...

The growing importance of subsurface carbon storage for tackling anthropogenic emissions requires new ideas to improve the rate and cost capture (CCS) project development implementation. We assessed sandstones from UK Geoenergy Observatories (UKGEOS) site in Glasgow, Wilmslow Sandstone Formation (WSF) Cumbria, at pore scale indicate suitability further assessment as CCS reservoirs. measured por...

Correspondence: Takahiro Sato Department of Gastroenterology, Sapporo Kosei General hospital, Kita 3 higashi 8, Chuo-ku, Sapporo 060-0033, Japan Tel +81 11 261 5331 Fax +81 11 261 6040 Email taka.sato@ja-hokkaidoukouseiren. or.jp Background and aims: The study’s aim was to evaluate the efficacy of endoscopic injection sclerotherapy (EIS) compared with endoscopic band ligation (EBL) in treating ...

BACKGROUND Emerging evidence indicates that accumulating physical activity in periods of less than 10 minutes, termed sporadic physical activity (SPA), has similar effects on health as a similar volume of bouted physical activity (BPA). The purpose of this study was to describe the volume and intensity of SPA in adults. METHODS Participants consisted of a representative sample of 6040 adults ...

-Secretase catalyzes the final cleavage of the -amyloid precursor protein to generate amyloidpeptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer’s disease. Here, we review the identification of -secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, -secretase was fou...

Objectives: The aim of this study was to investigate Endoscopic Ultrasonography with Color Doppler (ECDUS) findings of gastric varices and to determine the role of ECDUS in the diagnosis of gastric varices. Methods: Two hundred-fifteen patients with gastric varices found consecutively by routine upper endoscopy were evaluated with ECDUS. We monitored the color flow images of gastric varices, pa...