OBJECTIVE Studies have shown that transforming growth factor-beta (TGF-β) is associated with metastasis and chemoresistance of osteosarcoma. The TGF-β kinase inhibitor LY2109761 could inhibits metastasis and enhances chemosensitivity in several cancers, but its role and mechanisms in osteosarcoma (OS) is unclear. Here, we investigated the role and mechanism of LY2109761 on metastasis and chemos...

OBJECTIVE Relaxin-2 (RLN2) increases cell migration, invasiveness and proliferation in vitro of osteosarcoma cells, but the molecular mechanisms of this action are still unknown. In the present study, we identified S100A4 /MMP-9 signaling as a major mediator of the actions of RLN2 in osteosarcoma cells in vitro. MATERIALS AND METHODS We have established stable transfectants of osteosarcoma MG...

Epidemiological studies, especially cohort studies have many limitations in countries like India. The present population based molecular epidemiolohgical cohort study was planned to address the prevalence, risk factors and natural history of uterine cervical HPV infection in women in an area of suburban dwellings in South India. Epidemiological data, blood samples and cervical scrape smears wer...