The reversible regulation of myosin light chain phosphatase (MLCP) in response to agonist stimulation and cAMP/cGMP signals plays an important role in the regulation of smooth muscle (SM) tone. Here, we investigated the mechanism underlying the inhibition of MLCP induced by the phosphorylation of myosin phosphatase targeting subunit (MYPT1), a regulatory subunit of MLCP, at Thr-696 and Thr-853 ...

Abstract Aims Doxorubicin-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in breast cancer patients. Sacubitril–valsartan (LCZ 696) is a combination drug, made up neprilysin inhibitor sacubitril angiotensin II receptor blocker valsartan, used for treatment heart failure patients with reduced ejection fraction. We hypothesized that LCZ 696, administ...

Tirole J. Economics for the common good / Transl. from French by I. Sheveleva; Ed. of translation M. Levin. Moscow, Publishing House Gaidar Institute, 2020, 696 p.

Previous work shows that policies that subsidize new vehicles and tax size, miles, or gasoline efficiently reduce pollution. Less is known about their distributional effects. This paper examines distributional effects by estimating the joint demand for vehicles and miles, using the Consumer Expenditure Survey. Greater price responsiveness among low-income households enhances progressivity of ga...

northeast of China and Korea. Its root bark has been used as a folk medicine for tonic, anti-arthritic, and anti-diabetic effect. The young shoot of A. elata is a popular edible plant, especially in the spring in Korea and Japan. Many saponins have been isolated from this plant, and were reported to show anti-diabetic activity, cytoprotective effect on CCl4induced hepatic injury, ethanol absorp...

pathogenesis of various circulatory and neurodegenerative disorders such as thrombosis, atherosclerosis and Alzheimer’s disease, which is now thought to have an inflammatory base. The development of antiinflammatory agents which prevent the accumulation of leucocytes, platelet activation or lost of function of the vessel wall, could constitute new therapeutic strategies for the control of these...

In the originally published version of chapter 48, Table 1 and equation on page 696 contained errors. This has been corrected.