The synaptic interactions between catecholaminergic terminals and luteinizing hormone releasing hormone (LHRH)-containing neurons in the medial preoptic area of the rat was studied by electron microscopy using LHRH immunocytochemistry combined with 5-hydroxydopamine labeling or autoradiography after injection of 3H-dopamine or 3H-noradrenaline in the same tissue section. Axon terminals labeled ...

In the present study, PC12 cells induced by 6-hydroxydopamine as a model of Parkinson's Disease, were used to investigate the protective effects of bone marrow-derived mesenchymal stem cells bone marrow-derived mesenchymal stem cells against 6-hydroxydopamine-induced neurotoxicity and to verify whether the mechanism of action relates to abnormal α-synuclein accumulation in cells. Results showed...

1. The rat anococcygeus muscle possesses a dense motor adrenergic innervation and also a powerful inhibitory innervation whose transmitter is unknown. The possibility that the adrenergic nerves released both noradrenaline and the unknown inhibitory transmitter was investigated by destroying the adrenergic nerves either by immunosympathectomy or by 6-hydroxydopamine.2. Immunosympathectomy was on...

To investigate the mechanisms underlying motor hyperactivity, we performed intracisternal injection of 6-hydroxydopamine or endocrine disruptors in rats on postnatal day 5. 6-Hydroxydopamine (100 microg, 488 nmol) caused a significant increase in spontaneous motor activities at 4 weeks of age. Gene-expression profiling using a cDNA membrane array revealed alterations in several classes of gene ...

background and objective: parkinson’s disease (pd) is a common neurological disorder due to degeneration of dopaminergic neurons within pars compacta of substantia nigra (snc). with regard to protective effect of malva sylvestris (ms), this study was conducted to evaluate the effect of aquaeous extract of this plant in an experimental model of pd induced by 6-hydroxydopamine (6-ohda). materials...

The relationship between morphological and functional changes in adrenergic nerves and the development of supersensitivity in the rat vas deferens was comparatively investigated after surgical denervation, chemical sympathectomy by 6-hydroxydopamine, daily treatment of animals with reserpine, or local application of colchicine to the hypogastric plexus. The order of ability to produce supersens...

Hydrogen peroxide, superoxide radical, and hydroxyl radical were all formed during the autoxidation of four cytotoxic agents, namely, 6-hydroxydopamine, 6-aminodopamine, 6,7-dihydroxytryptamine, and dialuric acid. Ascorbic acid and 5-hydroxydopamine, two autoxidizable agents of biological interest but without similar cytotoxic actions, were used as negative controls. The results tend to implica...