Two novel indazole derivatives protected with p-methoxybenzyl group were synthesized and characterized. The crystal and molecular structure of 2-(4-methoxybenzyl)-4-nitro-2H-indazole as one out of the two regioisomers is reported. The compound was obtained from a saturated petroleum ether/ethyl acetate mixture and crystallizes in the triclinic space group P1. The unit cell parameters are: a = ...

In the title compound, C(10)H(6)BrN(3)O(2), the indazole fused-ring system is nearly planar (r.m.s. deviation = 0.008 Å); its nitro substituent is nearly coplanar with the fused ring [dihedral angle = 4.5 (2)°]. In the crystal, adjacent mol-ecules are linked by weak acetyl-ene-nitro C-H⋯O hydrogen bonds, generating a helical chain running along the b axis.

7-Nitro i n d a z o l e (7-NI), w h i c h is se lec t ive for t h e n e u r o n a l i s o f o r m of n i t r i c ox ide s y n t h a s e (NOS), was t e s t ed in a pass ive a v o i d a n c e task in t he ch ick . I n j ec t i on o f 50 m g / k g i.p. p r e t r a i n i n g h a d a m n e s i c effects for t he task w h e n t e s t ed 30 m i n , 2 o r 24 h r af ter t r a in ing . I n j ec t i ons p...

We examined the effect of 7-nitro indazole (7-NI, 2.5-50 mg/kg, i.p.), an inhibitor of central nitric oxide (NO) synthesis, on general behaviour and sleep. The results show that 7-NI induces ptosis, a loss of the righting reflex and decrease of the EEG amplitudes. Furthermore, a duration of slow wave sleep (SWS) and REM sleep decreased, while the latencies of SWS and REM sleep increased. The ef...

7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blo...