BACKGROUND It is well known that suspension laryngoscopy (SL) produces marked hemodynamic changes. Coughing during extubation sometimes causes adverse clinical problems. We investigated whether 10% lidocaine spray could attenuate hemodynamic stress responses due to SL and reduce coughing incidence during extubation. METHODS Sixty patients undergoing SL were randomly divided into two groups an...

Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult outpatients undergoing unsedated diagnostic UGE were randomized to receive either a bupivacaine lozenge (...

BACKGROUND Sympathetic response associated with laryngoscopy and endotracheal intubation is recognized as a potential cause for a number of complications especially in coronary bypass surgery patients. Various methods have been used to attenuate these hemodynamic responses, The aim of our study was to compare lidocaine spray in addition to intravenous morphine on attenuating the hemodynamic res...

OBJECTIVE To examine the effectiveness of lidocaine spray compared with conventional lidocaine submucosal injection during a loop electrosurgical excision procedure (LEEP). METHODS Women undergoing LEEP for any degrees of cervical intraepithelial neoplasia were invited to participate. The participants were randomly assigned into two groups. In group 1 (injection), the participants were anesth...

BACKGROUND The aim of this trial was to assess the relative efficacy of a sage/echinacea spray and a chlorhexidine/lidocaine spray in the treatment of acute sore throats. METHODS This was a multicenter, randomized, double-blind, double-dummy controlled trial carried out in eleven general practices in Switzerland. A total of 154 patients (133 analyzed in per protocol collective) at least 12 ye...

Electrical stimulation of neuromuscular system has been used in a variety of research and therapeutic applications. Although tri-polar transcutaneous electrical stimulation (TENS) is commonly used to change motoneuron excitabi1ity, but the effect of TENS on synaptic activities through dorsal column stimulation or cutaneous pathways is unknown. So, the aim of this research study was to determine...

Objective to assess the efficacy and safety of intrauterine bubivacaine instillation, lidocaine spray and paracervical block in outpatient hysteroscopy Design randomized controlled trial Setting university hospital Method A total of 160 women planned to do office hysteroscopy (outpatient hysteroscopy enrolled in this study). The study was performed using 5mL of isobaric bupivacaine hydrochlorid...

the aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. for this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and carbomers such as c974p, c971, c934p and c971 in the range of 0.01-0.1% were adde...

Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) Procedure- A loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose o...