Nonalcoholic fatty liver disease (NAFLD) includes simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The gut-derived endotoxin plays an essential role in the pathophysiological development and progression of NAFLD. By using rat models of choline-deficient/L-amino acid-defined (CDAA)-diet-induced NAFLD, we examined whether MIYAIRI 588--a but...

Akt substrate of 160 kDa (AS160) phosphorylation on Thr(642) and Ser(588) by Akt is essential for insulin's full effect on glucose transport. However, protein phosphorylation is determined by the balance of actions by kinases and phosphatases, and the specific phosphatase(s) controlling AS160 dephosphorylation is (are) unknown. Accordingly, we assessed roles of highly expressed skeletal muscle ...

PURPOSE To investigate the effects of repeated treatments with a neuroprotective compound, R(-)-1-(benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol hydrochloride (T-588), on retinal ganglion cell (RGC) survival in rat eyes with elevated intraocular pressure (IOP) or after optic nerve crush. METHODS An increase in IOP was induced by a single laser treatment to the trabecular m...

Background: In the previous study, we have shown that the presence of A allele at position -588 in Aγ-globin gene was highly frequent and closely associated with fetal hemoglobin elevation among β-thalassemia intermedia patients. Therefore, we decided to investigate whether this allele (A allele at -588) could result in an increase in Aγ-globin gene expression to ameliorate the severity of the ...

Robotica / Volume 31 / Issue 04 / July 2013, pp 573 588 DOI: 10.1017/S0263574712000598, Published online: 19 October 2012 Link to this article: http://journals.cambridge.org/abstract_S0263574712000598 How to cite this article: Xuefeng Zhou, Yisheng Guan, Li Jiang, Haifei Zhu, Chuanwu Cai, Wenqiang Wu and Hong Zhang (2013). Stability of biped robotic walking with frictional constraints. Robotica...

Received July 6, 1 979; accepted after revision October 30, 1979. 1Department of Radiology, Division of Nuclear Medicine and Ultrasound, New England Medical Center Hospital, 1 71 Harrison Ave., Boston, MA 021 1 1. Address reprint requests to P. C. Kahn. 2Department of Obstetrics and Gynecology, New England Medical Center Hospital, 1 7i Harrison Ave., Boston, MA 02111. AJR 134:588-589, March 198...

An emerging respiratory infectious disease with high mortality, Middle East respiratory syndrome (MERS), is caused by a novel coronavirus (MERS-CoV). It was first reported in 2012 in Saudi Arabia and has now spread to eight countries. Development of effective therapeutics and vaccines is crucial to save lives and halt the spread of MERS-CoV. Here, we show that a recombinant protein containing a...

Bath application of compound T-588, a neuroprotective agent, reduced paired-pulse and repetitive-pulse facilitation at mammalian and crustacean neuromuscular junctions. In addition, it reduced voltage-gated sodium and potassium currents in a use-dependent fashion, but had only a small effect on the presynaptic Ca(2+) conductance. By contrast, it blocked FM 1-43 vesicular uptake but not its rele...

It has been recently proposed that in addition to bacteriorhodopsin, Halobacterium halobium membranes contain a second light-reactive pigment, whose function is the translocation of sodium ions. The evidence is based on the presence of light-driven, uncoupler-insensitive, sodium ion extrusion and light-driven, uncoupler-enhanced, passive proton uptake in cell envelope vesicles prepared from H....