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Alzheimer’s disease (AD) is the most common cause of age-related neurodegeneration and cognitive decline. AD more commonly occurs in females than males, so it necessary to consider new treatments specifically targeting this population. The present study investigated protective effects Begacestat (γ-secretase inhibitor-953, GSI-953) bone marrow-derived mesenchymal stem cells (BM-MSCs) during pre...
288 Received 18 November 2014, Revised 23 November 2014, Accepted 14 December 2014 Correspondence: Ashley Smith ([email protected]) Tel: 1-904-953-7903, Fax: 1-904-953-1010 cc This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, dist...
Journal of Comparative NeurologyVolume 531, Issue 9 p. 953-953 ISSUE INFORMATION - TOCFree Access The Neurology, Table Content, Vol. No. 9, June, 2023 First published: 16 April https://doi.org/10.1002/cne.25364AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box be...
Corresponding author: Dr Luke Chen, Clinical Research, Infectious Diseases Unit, The Alfred Hospital, Melbourne 3000. Telephone: +61 3 9276 3000. Facsimile: +61 3 953
Bulletin of the Korean Chemical SocietyVolume 42, Issue 7 p. 953-953 CoverFree Access Cover BKCS 7/2021 First published: 27 July 2021 https://doi.org/10.1002/bkcs.12025AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read acce...
The presenilin containing gamma-secretase complex is responsible for the regulated intramembraneous proteolysis of the amyloid precursor protein (APP), the Notch receptor, and a multitude of other substrates. gamma-Secretase catalyzes the final step in the generation of Abeta(40) and Abeta(42) peptides from APP. Amyloid beta-peptides (Abeta peptides) aggregate to form neurotoxic oligomers, seni...
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