a0201

An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH3 Encodes for HLA-A0201-Restricted CD8+ Cytotoxic T Cell Epitopes

Journal: :PLoS ONE 2011

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Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.

Journal: :Journal of Experimental Medicine 1995

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Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

2015

Stephen Q. Wong Andreas Behren Victoria J. Mar Katherine Woods Jason Li Claire Martin Karen E. Sheppard Rory Wolfe John Kelly Jonathan Cebon Alexander Dobrovic Grant A. McArthur

Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. Screening in 715 additional primary melanomas revealed a prevalence of ~4%. This represents the first repor...

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The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy.

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007

Claudia Palena Dmitry E Polev Kwong Y Tsang Romaine I Fernando Mary Litzinger Larisa L Krukovskaya Ancha V Baranova Andrei P Kozlov Jeffrey Schlom

PURPOSE Identification of tumor antigens is essential in advancing immune-based therapeutic interventions in cancer. Particularly attractive targets are those molecules that are selectively expressed by malignant cells and that are also essential for tumor progression. EXPERIMENTAL DESIGN AND RESULTS We have used a computer-based differential display analysis tool for mining of expressed sequ...

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Antitumor effect of new multiple antigen peptide based on HLA-A0201-restricted CTL epitopes of human telomerase reverse transcriptase (hTERT)

Journal: :Cancer Science 2012

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PRAME-specific CD8+ T cells are spontaneously present in a large proportion of healthy donors and leukemic HLA-A0201 patients

Journal: :Biology of Blood and Marrow Transplantation 2005

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Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals

Journal: :Vaccine 2011

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طراحی و تولید واکسن dna پلی توپ حاوی ژن hbsag برای ایجاد ایمنی محافظ علیه ویروس هپاتیت سی

ژورنال: :فیض 0

آرش معمارنژادیان arash memarnejadian انستیتوپاستور ایران فرزین روحوند farzin roohvand department of hepatitis & aids, nrgb lab, pasteur institute of iranتهران، خیابان پاستور، انستیتو پاستور ایران، بخش هپاتیت و ایدز، بانک ژن نوترکیب ایران، کد پستی: 1316943551 فاطمه متولی fatemeh motevalli محمد رضا آقاصادقی mohammad reza aghasadeghi

سابقه و هدف: با توجه به اثر تضعیف کنندگی سیستم ایمنی و موتاسیونهای شایع در برخی آنتی ژنهای ویروس هپاتیت سی ( hcv )، القاء پاسخ متمرکز سلولهای tcd8+ بر اپیتوپهای نامتغیر و مهم ویروس در قالب یک واکسن چند اپی توپی میتواند مانع از مزمن شدن بیماری گردد. مواد و روشها: این مطالعه به صورت تجربی صورت گرفت؛ به این ترتیب که دو اپیتوپ غالب وابسته به hla-a2 انسانی (شامل e2614-622 و ns31406-1415 ) و ...

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HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease

Journal: :PLoS Neglected Tropical Diseases 2008

María G. Alvarez Miriam Postan D. Brent Weatherly María C. Albareda John Sidney Alessandro Sette Carina Olivera Alejandro H. Armenti Rick L. Tarleton Susana A. Laucella

BACKGROUND Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. METHODS AND FINDINGS Herein, we report the identification of peptides encoded by the same trans-sialidase gene family that bind alleles representative of the 6 most common class I HLA-supertypes. Based on a...

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Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.

Journal: :Journal of immunology 1999

U Gileadi H T Moins-Teisserenc I Correa B L Booth P R Dunbar A K Sewell J Trowsdale R E Phillips V Cerundolo

Generation of the HLA-A0201 (A2) influenza Matrix 58-66 epitope contained within the full-length Matrix protein is impaired in cells lacking the proteasome subunits low molecular protein 2 (LMP2) and LMP7. This Ag presentation block can be relieved by transfecting the wild-type LMP7 cDNA into LMP7-deficient cells. A mutated form of LMP7, lacking the two threonines at the catalytic active site, ...

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