Reaction of 5S RNA with chlorocetaldehyde leads to the conversion of unpaired adenines to the fluorescent 1,N6-etheno-adenine derivatives. Up to 16 of the 23 adenines in free 5S RNA can be modified, the fastest reacting are A29, A34, A57-59. Partial modification of adenines in this area results in a 20% reduction in the efficiency of 5S RNA incorporation into 50S subunits during reconstitution ...

During the period 1980-6 102 patients from 14 European eye clinics were diagnosed as having birdshot chorioretinopathy (BSCR). All were Caucasian, and the series consisted of 47 men and 55 women, with a mean age of 52.5 years. The major findings in this rare disorder concern the ocular fundus. Most marked are the patterned distribution of depigmented spots without hyperpigmentation, radiation f...

HIGHLIGHT Histopathology of birdshot retinochoroidopathy Birdshot retinochoroidopathy is a chronic posterior segment inflammatory disease with a characteristic clinical presentation and strong correlation with the HLA-A29 antigen. 1 2 In this report, we describe the his-topathological findings in the eye of a patient with this disease. A 49 year old white man was referred to the Proctor Medical...

BIRDSHOT RETINOCHOROIDITIS: THE ORIGINS OF THE DISEASE NAME Birdshot retinochoroiditis (BRC) is a uveitis predominantly affecting the posterior segment of the eye with dual, independent retinal and choroidal inflammation and almost only seen in Caucasians. 2 Ryan and Maumenee first described the bilateral retinochoroidal inflammatory disease in early 1980, reporting on 13 patients. These author...

represents the dominant virus subtype. It does not provide sufficient information to resolve transmission events particularly for rapidly spreading viruses. However, changes in the composition of minor variants between hosts and the pattern of minor variants fixation during outbreaks, could provide additional high-resolution data on who is infecting whom. The same data could also potentially in...