نتایج جستجو برای: aamyotrophic lateral sclerosis
تعداد نتایج: 178071 فیلتر نتایج به سال:
Amyotrophic lateral sclerosis is a neurodegenerative disease that is incurable and results in paralysis of the muscles. Different forms of amyotrophic lateral sclerosis are explained with case studies to demonstrate how they are diagnosed in real patients. Two forms of magnetic resonance imaging (MRI) are discussed showing how the disease affects the human brain. Electromyography is used to dia...
background: as a disease of motor nervous system (motor neuron disease), amyotrophic lateral sclerosis (als) has a great impact on several aspects of quality of life (qol). generic questionnaires of qol do not address all the especial features of als and therefore translation and validation of disease specific questionnaires such as amyotrophic lateral sclerosis assessment qu...
Knowledge about the nature of pathomolecular alterations preceding onset of symptoms in amyotrophic lateral sclerosis is largely lacking. It could not only pave the way for the discovery of valuable therapeutic targets but might also govern future concepts of pre-manifest disease modifying treatments. MicroRNAs are central regulators of transcriptome plasticity and participate in pathogenic cas...
CASE NUMBER 1. Mr. M. W., a 41-year old white male was admitted to the Victoria General Hospital with complaints of twitching in the left arm and legs, and weakness of the left hand. Seven to eight years prior to admission, the patient noticed dull muscle pain in his arms and legs, lasting four to five days at a time. The pain worsened as the day passed and was neither aggravated nor relieved b...
OBJECTIVE The aim of this study was to investigate unidimensionality and differential item functioning of the SF-36 physical functioning scale (PF10) in patients with various neurological disorders. PATIENTS PATIENTS post-stroke (n = 198), with multiple sclerosis (n = 151) and amyotrophic lateral sclerosis (n = 193) participated. METHODS Unidimensionality of the PF10 within the patient grou...
Primary lateral sclerosis is a sporadic disorder characterized by slowly progressive corticospinal dysfunction. Primary lateral sclerosis differs from amyotrophic lateral sclerosis by its lack of lower motor neuron signs and long survival. Few pathological studies have been carried out on patients with primary lateral sclerosis, and the relationship between primary lateral sclerosis and amyotro...
A large hexanucleotide (GGGGCC) repeat expansion in the first intron of C9ORF72, a gene located on chromosome 9p21, has been recently reported to be responsible for ~40% of familial amyotrophic lateral sclerosis cases of European ancestry. The aim of the current article was to describe the phenotype of amyotrophic lateral sclerosis cases carrying the expansion by providing a detailed clinical d...
amyotrophic lateral sclerosis (als), the most common form of motor neuron disease, is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless progression towards death. therefore, all efforts must be made by the clinician to exclude alternative and more treatable entities. als with laboratory abnormalities of uncertain significance is...
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