Methods We performed a cross sectional analytic observational study. One hundred twenty three obese children, ages 10 – 14 years with and without acanthosis nigricans got examined for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). Diagnosis of acanthosis nigricans is confirmed by a dermatologist. This study took place in Wenang district, Manado, Nor...

Acanthosis nigricans is thickened, velvety, hyperpigmented skin associated with a variety of endocrine disorders, malignancies and medications.

Metabolic syndrome refers to a clustering of metabolic risk factors including central obesity, glucose intolerance, hyperinsulinemia, low HDL cholesterol, high triglycerides and hypertension. MS is increasingly being recognized as a risk factor for cardiovascular disease and cardiovascular mortality. Lipoatrophy, acanthosis nigricans is a skin markers associated with this syndrome.Acanthosis ni...

Diffuse cutaneous hyperpigmentation may have various causes: endocrine, metabolic, autoimmune, melanosis secondary to metastatic melanoma, drug or heavy metal poisoning. A cause to remember is acanthosis nigricans, which, in the form of paraneoplastic syndrome may be the first or even the only clinical manifestation of a cancer. The most common cause of malignant acanthosis nigricans is the gas...

Localized acanthosis nigricans at the insulin injection site is a rare skin disorder in patients with diabetes mellitus. We report co-existence of acanthosis nigricans and lipoatrophy at injection sites in the same patient with type 1 DM. A 23 year old male patient with a history type 1 DM for 11 years was admitted to hospital due to recurrent diabetic ketoacidosis attacks. There were two lesio...

Rabson-Mendenhall syndrome (RMS) is an autosomal recessive disorder due to mutations in the insulin receptor gene (INSR) which is mapped to 19p13.2. RMS is characterized by acanthosis nigricans, generalized lanugo, tooth and nail dysplasia, high nasal bridge, and growth retardation. A 5-year-old female patient was referred due to acanthosis nigricans and generalized lanugo. On her physical exam...

BACKGROUND The sudden appearance of acanthosis nigricans on the skin of an individual is highly suggestive of an underlying clinical disease. However, there is no information on its possible association with head and neck disease in our environment. OBJECTIVE To determine the prevalence of acanthosis nigricans and identifying the underlying associated medical and oncologic factor in an Otorhi...

conclusions metabolic abnormalities in bscl may prove fatal necessitating optimal therapeutic and preventive measures. patients are advised low fat diet with enhanced physical activities. other treatments include metformin, n-3 polyunsaturated fatty acids and leptin replacement for correction of metabolic complications. we report this case of bscl in view of its rarity. case presentation an 18 ...