URING the last half of the twentieth century, pertussis vaccine has been at the center of controversies over the evaluation and marketing of vaccines for children. This controversy has transcended the simple confines of scientific research to redefine relationships among industry, government, law, and consumer advocacy. The dangerous side effects of whole-cell pertussis vaccine have been known ...

Whooping cough and diphtheria are vaccine preventable diseases. Diphtheria, due to Corynebacterium diphtheriae or Corynebactium ulcerans, two Gram positive bacteria, is a serious upper respiratory tract disease with high morbidity and mortality rates. Vaccination, via an acellular vaccine composed only of purified, detoxified diphtheria toxin, has significantly reduced the incidence of the dise...

Efficacy of whole cell pertussis vaccines (wP) in humans correlates with (and hence is measured by) the ‘mouse protection test’, wherein vaccinated mice are challenged with live B. pertussis. This test does not work similarly with acellular pertussis vaccines (aP); hence antibody levels to various antigens are measured as a surrogate marker of efficacy. This difference between the direct as com...

presented at the Acellular Pertussis Vaccine Confer­ence, Bethesda, MD. Mooi, F. R., et al. (1998). Polymorphism in the Bordetella pertus­sis virulence factors P69/pertactin and pertussis toxin in theNetherlands: Temporal trends and evidence for vaccine-driven evolution. Infection and Immunity, 66, 670-675. Strebel, P., et al. (2001). Population-based incidence of pertussisamong...

BACKGROUND The transition from a whole-cell to a 5-component acellular pertussis vaccine provided a unique opportunity to compare the effect that each type of vaccine had on the incidence of pertussis, under routine conditions, among children less than 10 years of age. METHODS Analyses were based on passive surveillance data collected between 1995 and 2005. The incidence of pertussis by year ...

In August 1997, a workshop was convened by the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases to consider current issues in the use of pertussis vaccines and implications for the Australian immunisation schedule. Topics covered included the history, efficacy and reactogenicity of whole-cell and acellular vaccines and vaccine schedules. Acellular pertu...

Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vac...

whooping cough and diphtheria are vaccine preventable diseases. diphtheria, due to corynebacterium diphtheriae or corynebactium ulcerans, two gram positive bacteria, is a serious upper respiratory tract disease with high morbidity and mortality rates. vaccination, via an acellular vaccine composed only of purified, detoxified diphtheria toxin, has significantly reduced the incidence of the dise...