We describe highly enantioselective synthesis of -amino acid derivatives (1a-c) using asymmetric hydrogenation of -aminomethylacrylates (2a-c), which contain a free basic NOH group, as the key step. The -aminomethylacrylates (2a-c) were prepared using the Baylis– Hillman reaction of an appropriate aldehyde with methyl acrylate followed by acetylation of the resulting allylic alcohols (4a-b) and...

Multiple sustainable methodologies were developed for the chemical upgrading of HMF: i) at 30–90 °C, highly selective base-catalyzed acetylation and carboxymethylation reactions HMF with nontoxic reagents as isopropenyl acetate (iPAc) dimethyl carbonate (DMC) achieved to prepare corresponding ester products, (5-formylfuran-2-yl)methyl (5-formylfuran-2-yl) methyl carbonate, respectively; ii) bas...

The selectivity of acetylation of delta-functionalized secondary alcohols catalyzed by Candida antarctica lipase B has been examined by molecular dynamics. The results from the simulation show that a delta-alcohol functionality forms a hydrogen bond with the carbonyl group of Thr 40. This interaction stabilizes the tetrahedral intermediate and thus leads to selective acetylation of the R enanti...

In the present work, we have developed an efficient catalytic procedure for the chemo-selective acetylation of various substrates like amines, phenols and alcohols into their corresponding acetylated products using acetyl chloride in the presence of catalytic amount of metal acetylacetonates covalently anchored onto amine functionalized silica under solvent-free conditions. The catalysts were c...

Tightening legislation on the emission of hazardous pollutants is driving chemical industries towards the implementation of innovative “clean technology” including the use of alternative heterogeneously catalyzed processes. This prompted us to examine the catalytic potential of Indian clays for fine chemical synthesis. Catalytic activity of clay minerals from India was only less studied. In the...

To investigate the affinity of acetylated wood for organic liquids, Yezo spruce wood specimens were acetylated with acetic anhydride, and their swelling in various liquids were compared to those of untreated specimens. The acetylated wood was rapidly and remarkably swollen in aprotic organic liquids such as benzene and toluene in which the untreated wood was swollen only slightly and/or very sl...

microglia is the effector cell of the innate immune system in central nervous system (cns). these cells mediate inflammatory responses in injuries. besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. mechanisms of epigenetic regulation mainly consist of dna methylation, histone modifications and use of non-coding rnas. recent s...

Acetylation with acetic anhydride, under both aqueous and anhydrous conditions, has been utilized to derivatize various biogenic amines and psychotropic drugs for subsequent analysis by gas chromatography (GC) or gas chromatography-mass spectrometry (GC-MS). Under basic aqueous conditions, acetic anhydride derivatizes phenols and amines but not alcohols; under anhydrous conditions, all three fu...