Catecholamines and acetylcholine have dissociable effects on large-scale cortical network activity behavior.

A blocker of postsynaptic acetylcholine receptors was isolated from venom of the Eastern green mamba Dendroaspis angusticeps, by gel filtration, ion-exchange and reverse phase high performance liquid chromatography. The isolated component blocks neuromuscular transmission and responses to exogenously applied acetylcholine in isolated chick biventer cervices preparations. These results suggest t...

Background and Aims: Our previous study has demonstrated that essence of Carum copticum reduces contraction activity of ileum in rat. The present study was designed to find out the effects of nonpolar fraction of Carum copticum essence (NFCCE) on mechanical activity of the isolated ileum in rat. Materials and Methods: For evaluation of spasmolythic property of fraction, different doses of the ...

teucrium polium l. (lamiaceae) is used in the traditional medicine of iran for the treatment of disorders of the gastrointestinal tract. the essential oil from the aerial parts of t polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. acetylcholine and kc i were used for induction of contraction on rat isolated ileum. teucrium polium essential...

the present work with consideratlon to the autoradiographic pictures, suggests that cholinergic receptors are located at the gate of a channel originating from synaptic cleft coming to lie within the muscle fibre. ache molecules stand at the gate of this channel,controlling the entrance of different cholinergic agents. it was report- ••• ed previously that dtc molecules s t.abd ;:.2e the ache r...

the exact role of the epithelial lining of the trachea in modulating the bronchial tone is controversial. the present study was an attempt to verify the role of both prostaglandins and mast cells in the acute phase of acid inspiration in rat. four groups (n = 6) of n. mari rats were employed. the first group was used as placebo control, and normal saline was injected. to the second group hydroc...

the hypotensive effect of garlic has been well-documented in human subjects and animals. since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effe...

isovanillin and isoacetovanillon are two components found in p. spinosa decne.exboiss extract with no previously reported effect on ileum contractions. spasmolytic effect of isovanillin and isoacetovanillon were examined on response to electrical field stimulation (efs), acetylcholine (ach) and 5-ht in strips of rat ileum. longitudinal ileum strips were set up in an organ bath containing oxygen...

Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...