teucrium polium l. (lamiaceae) is used in the traditional medicine of iran for the treatment of disorders of the gastrointestinal tract. the essential oil from the aerial parts of t polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. acetylcholine and kc i were used for induction of contraction on rat isolated ileum. teucrium polium essential...

The response of canine tracheal and bronchial smooth muscle to i.a. administered agonists causing smooth muscle contraction was compared in 22 mongrel dogs in vivo. Tracheal and bronchial contractile responses were measured isometrically in situ in the same dogs. In nine dogs, dose-response curves were generated with i.a. acetylcholine and histamine (10(-10) to 10(-6) mol) in a 4-cm tracheal se...

The motor functions of the stomach have traditionally been regarded to have regional differences. However, to date there have been only a few data investigating whether such regional differences in motor function exist in the human stomach. The aims of the present study were to examine the spontaneous activity and responses to acetylcholine in the anatomically defined regions of human stomach. ...

the purpose of the work presented here was to investigate endotheliumdependent relaxations in the rabbit coronary ligation model of heart failure. we investigated endothelium-dependent relaxations at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear v...

- verapamil produces a sustained contraction in isolated biventer-cervicis muscle of chickens between 2-8 days old. from cumulative dose-response curves, ed50 of was calculated for this effect of verapamil. when isolated chicken biventer-cervicis muscle was electrically stimulated, verapamil had no effect on twitch contractures but increased the base line tone of the muscle. glycerol treatment ...

AIMS There are many biological investigations for determining an effective cure for the dysfunction of gastrointestinal tracts, using herbal medicine. It has been reported that Carum Copticum is a bactericidal agent and possesses anticholinergic, antihistaminic and b-adrenergic stimulatory effects in some tissues. However, these effects of Carum Copticum on mechanical activities of isolated int...

To understand the meaning of blending crude drugs in Chinese medicinal prescriptions, the influence of Saussurea root on the pharmacological action of Corydalis tuber was examined. Saussurea root increased the depression of acetylcholine-induced contraction caused by the hot water extract solution of Corydalis tuber in mouse ileum at low dosage, which showed no direct influence on acetylcholine...

Patil, Suresh B., Mercy D. Pawar, and Khalil N. Bitar. Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKC . Am J Physiol Gastrointest Liver Physiol 286: G635–G644, 2004. First published October 30, 2003; 10.1152/ ajpgi.00261.2003.—Reorganization of the cytoskeleton and association of contractile proteins are important steps in modulating smooth muscle contract...

The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. Isoproterenol and aminophylline non-selectively inhibited both the contraction evoked by vagus nerve- and that by transmural field-stimulation, ...

The purpose of the work presented here was to investigate endotheliumdependent relaxations in the rabbit coronary ligation model of heart failure. We investigated endothelium-dependent relaxations at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal e...