World Alzheimer Report of 2015 [1] has estimated that 46.8 million people are currently living with dementia worldwide which will be further increased to 74.7 million by 2030 and 131.5 million by 2050. Alzheimer’s disease (AD) is a neuro-degenerative disorder and common form of dementia, which progress gradually with the age. The common symptom of AD is memory impairment and cognitive shortfall...

The present study investigates the potential of lansoprazole (a proton pump inhibitor and agonist of liver x receptors) in experimental dementia of AD type. Streptozotocin [STZ, 3 mg/kg, injected intracerebroventricular (i.c.v), and high fat diet (HFD, administered for 90 days)] were used to induce dementia in separate groups of Swiss mice. Morris water maze (MWM) test was performed to assess l...

A 26-year-old lady was referred for evaluation of dysphagia. The patient had consumed 50 ml of organophosphorus (OP) components of liquid pesticide 4 months ago and was on ventilatory support with a tracheostomy tube because of OP-poisoning-induced respiratory failure. Treatment included injection of atropine, pralidoxime and other supportive care, and the patient recovered. The patient develop...

Alzheimer's disease (AD) is characterized by profound memory loss sufficient to interfere with social and occupational functioning. It is the most common form of dementia, affecting more than 20 million people worldwide. AD is characterized by an insidious loss of memory, associated functional decline, and behavioral disturbances. Patients may live for more than a decade after they are diagnose...

Memory disorders are the progressive neurological disorder, mainly causing dementia, memory loss and cognitive dysfunctions. The current study is aimed to experimentally validate crude extract of Canna indica aerial parts (CIA) root (CIR) against aluminium chloride induced altered in rats. Initially, methanolic CIA, hydroalcoholic CIR, their combination CIA + CIR were screened for Invitro antio...

Alzheimer's disease is an irreversible and progressive brain disorder that slowly destroys memory and thinking skills and ultimately the ability to do the simplest things and can lead to death. Cholinesterases (ChEs) play an important role in controlling cholinergic transmission, and subsequently, by inhibiting CHEs, acetylcholine levels in the brain are elevated. Coumarins have been shown to e...

47 48 Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder clinically 49 characterized by loss of memory and cognition. Cholinergic deficit and oxidative stress have 50 been implicated in the pathogenesis of AD. Therefore, inhibition of acetylcholinesterase and 51 oxidation are the two promising strategies in the development of drug for AD. Phyllanthus 52 acidus, bel...

BACKGROUND AND OBJECTIVES Insulin resistance of the brain is a specific form of type2-diabetes mellitus (T2DM) and the active insulin-signaling pathway plays a neuroprotective role against damaging conditions and Alzheimer's progression. The present study identifies the mediated emerging effects of the Nigella sativa oil (NSO) on the memory enhancing process, its anti-oxidative, acetylcholinest...

BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by loss of memory and cognition. Cholinergic deficit and oxidative stress have been implicated in the pathogenesis of AD. Therefore, inhibition of acetylcholinesterase and oxidation are the two promising strategies in the development of drug for AD. Phyllanthus acidus, belonging to the famil...

Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. Amyloid β (Aβ) is the major constituent of NPs and plays a causative rol...