Temporal lobe epilepsy is the most common form of epilepsy, and current antiepileptic drugs are ineffective in many patients. The endocannabinoid system has been associated with an on-demand protective response to seizures. Blocking catabolism would elicit effects, devoid psychotropic effects. We herein report discovery selective anandamide catabolic enzyme fatty acid amide hydrolase (FAAH) inh...

The influence of the chemical structure of the amino acid (or amino acid analogue) moiety of a number of synthetic cholyl amidates on deconjugation by cholylglycine hydrolase from Clostridium perfringens was studied in vitro at pH 5.4. Conjugates with alkyl homologues of glycine were hydrolyzed more slowly as the number of methylene units increased (cholylglycine greater than cholyl-beta-alanin...

Inspired by the medicinal properties of plant Cannabis sativa and its principal component (?)- trans-? 9 -tetrahydrocannabinol (THC), researchers have developed a variety compounds to modulate endocannabinoid system in human brain. Inhibitors fatty acid amide hydrolase (FAAH) monoacylglycerol lipase (MAGL), which are enzymes responsible for inactivation endogenous cannabinoids anandamide 2-arac...