BACKGROUND Incomplete control of troublesome regurgitation and extraesophageal manifestations of chronic gastroesophageal reflux disease (GERD) is a known limitation of proton pump inhibitor (PPI) therapy. This multicenter randomized study compared the efficacy of transoral incisionless fundoplication (TIF) against PPIs in controlling these symptoms in patients with small hiatal hernias. METH...

A 66-year-old woman was diagnosed with hepatic metastasized carcinoid tumor of the ileocecal junction resulting in elevated plasma chromogranin A levels and urinary 5-hydroxyindoleacetic acid (5-HIAA) levels. Further examination showed right-sided heart failure with severe tricuspid valve regurgitation. Carcinoid tumors produce serotonin which leads to flushing, secretory diarrhea, bronchospasm...

BACKGROUND If a patient develops foregut symptoms after a fundoplication, it is assumed that the operation has failed, and acid-reducing medications are often prescribed. Esophageal function tests (manometry and pH monitoring) are seldom performed early in the management of these patients. HYPOTHESIS In patients who are symptomatic after fundoplication for gastroesophageal reflux disease, a s...

BACKGROUND/AIMS The sensitivity of the upper and lower esophageal mucosa to acid is considered to differ. We investigated the relationship between pH changes in different sites of the esophagus and generation of gastroesophageal reflux symptoms during an acid infusion test. METHODS An acid infusion catheter was placed at 5 or 15 cm above the lower esophageal sphincter (LES) in 18 healthy volu...

background: moderate non-organic tricuspid regurgitation (tr) concomitant with coronary artery disease is not uncommon. whether or not tr improves after pure coronary artery bypass grafting (cabg), however, is unclear.   the aim of this study was to evaluate the effect of isolated cabg on moderate non-organic tr. methods: this study recruited 50 patients (40% female, mean age: 65.38 ± 8.01 year...

background: gastroesophageal reflux disease (gerd) is a common disorder in the western population but detailed population-based data in iran is limited. the aim of this study was to investigate the prevalence of gerd in esfahan. materials and methods: a population-based study was conducted in 2004. major gerd symptoms (heartburn and acid regurgitation) were assessed through an interview by six ...

results of the 41 patients with dcm, echocardiography examination revealed 11 patients (27%) without mitral regurgitation and 12 (29%) with mild, 11 (27%) with moderate, and seven (17%) with severe mitral regurgitation. all of the morphological and functional parameters of left ventricle, atrium and mitral valve in dcm patients were greater than those in healthy subjects (all p < 0.05), except ...

BACKGROUND AND AIMS Patients with repaired tetralogy of Fallot may develop chronic right ventricular dysfunction and hepatic congestion over time. We hypothesized that bile acid metabolism is altered in repaired tetralogy of Fallot patients and therefore sought to correlate right ventricular indices with serum bile acid levels. METHODS Indexed right ventricular end diastolic volume, as assess...

background: gastroesophageal reflux disease (gerd) is one of the most common gastrointestinal problems in the west while different reports indicate an increase in the prevalence in iran. the aim of this study was to estimate the preva­lence and clinical spectrum of gerd in staff of a referral hospital and evaluate the risk factors. methods: this cross-sectional study using a modified mayo clini...

background: in cases of moderate(2 or 3+ on a scale of 0 to 4+) nonorganic mitral regurgitation (mr) and coronary artery disease, operative strategy continues to be debated between coronary artery bypass grafting alone (cabg) or concomitant valve repair. to clarify the optimal management of these patients, we evaluated the mid-term results of isolated cabg in the study group. methods: from marc...