Temporary tinnitus is a common consequence of noise exposure, and may share important mechanisms with chronic tinnitus. Noise-induced hearing loss is the most prevalent cause of chronic tinnitus. The reversibility of temporary tinnitus offers some practical experimental advantages. We therefore adapted a behavioral method based on gap detection to measure temporary tinnitus following brief acou...

BACKGROUND Previous microarray analysis showed that growth hormone (GH) was significantly upregulated following acoustic trauma in the zebrafish (Danio rerio) ear suggesting that GH may play an important role in the process of auditory hair cell regeneration. Our objective was to examine the effects of exogenous and endogenous GH on zebrafish inner ear epithelia following acoustic trauma. MET...

Hearing loss induces plasticity in excitatory and inhibitory neurotransmitter systems in auditory brain regions. Excitatory-inhibitory balance is also influenced by a range of neuromodulatory regulatory systems, but less is known about the effects of auditory damage on these networks. In this work, we studied the effects of acoustic trauma on neuromodulatory plasticity in the auditory midbrain ...

Spontaneous firing rates of neurons in the central auditory pathway, such as in the inferior colliculus, are known to be increased after cochlear trauma. This so-called hyperactivity is thought to be involved in the generation of tinnitus, a phantom auditory perception. Recent research in an animal model suggests behavioural signs of tinnitus can be significantly reduced by silencing or removal...

As stated in the conclusions of the HFM-192 report on hyperbaric oxygen therapy (HBOT) in military medical setting, acoustic trauma is a frequent consequence of military activity in operation. Acoustic trauma refers to an acute hearing loss following a single sudden and very intense noise exposure. It differs from chronic noise induced hearing (NIHL) loss in that it is usually unilateral and ca...

Acoustic trauma is one of the major causes of hearing loss and tinnitus, particularly in industrial environments. Noise-induced hearing loss (NIHL) results in direct mechanical damage as well as in indirect metabolic processes. Metabolic disorders have multiple origins: ionic, ischemic, excitotoxic and production of cochlear free radicals causing cell death, due to necrosis or apoptosis. The ef...