BACKGROUND Acral benign melanocytic lesions in white populations, particularly in subjects with atypical mole syndrome, have been poorly characterized until recently. The advent of dermoscopy has enabled more specific diagnoses of these pigmented skin lesions. OBJECTIVE To evaluate the clinical and dermoscopic features of benign volar lesions in a group of white patients with atypical mole sy...

Studies surveying melanomas associated with melanocytic nevi in Asia are rare. In this study, we examined whether nevus-associated melanomas differ from de novo melanomas in terms of their associations with clinical factors, histologic characteristics, and patient survival in Taiwan. Using data on cancer cases obtained from the Department of Pathology archives and the Cancer Registry of Nationa...

Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40-125 cases/million but targeted universal screening studies have found a higher prevalence (about 10 fold). The aim of the ACROSAHS study was to investigate the prevalence of acromegaly and acromegaly comorbidities in patients with sleep apne...

BACKGROUND Most studies on dermoscopy of acral lesions were conducted in Asian populations. In this study, we analyzed these features in a predominantly Caucasian population. OBJECTIVE Estimate the prevalence of dermoscopic features in acral lesions, and assess their level of agreement between observers. METHODS In this retrospective multicenter study, 167 acral lesions (66 melanomas) were ...

Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called a...

Objective The main objective of this paper is to emphasize the importance of the early diagnosis of certainty in the cases of acral-acroma malignant melanoma in order to increase the survival rate. Method The paper is a review of specialty literature and presents a clinical case of acral-acroma malignant melanoma. Clinical case: acral-acroma malignant melanoma with confirmed lymph node metast...

Myxoid DFSP expresses apolipoprotein D and presents with a storiform pattern and characteristic subcutaneous infiltration. Diagnosis is confirmed by detection of the chromosomal translocation t(17;22). The differential diagnosis should include benign myxoid lesions with spindle-shaped cells (myxoid neurofibroma, superficial angiomyxoma, mucous cyst), malignant myxoid lesions with spindle-shaped...

OBJECTIVE To characterize the dermoscopic features of acral congenital melanocytic nevi (CMN). DESIGN Retrospective independent evaluation of dermoscopic images by 2 dermoscopists. SETTING A dermatology clinic at a university hospital. PATIENTS Using the files of the clinic from January 1, 2004, through February 28, 2009, we selected cases with CMN lesions affecting acral volar skin that ...

Recent technological advances in cancer genomics make it possible to dissect complicated genomic aberrations of melanomas. In particular, several specific genomic aberrations including 11q13 amplification and KIT aberrations have been identified in acral melanomas. We recently identified NUAK2 at 1q32 as a promising oncogene in acral melanomas and reported its significant roles in tumorigenesis...

AAOC: acral angioosteoma cutis BMP: bone morphogenic protein PG: pyogenic granuloma VEGF: vascular endothelial growth factor INTRODUCTION Googe et al in 2006 first described 11 cases of acral angioosteoma cutis (AAOC), characterized by benign vascular and osseous lesions on acral skin. Since then, there have been only 3 additional cases reported. This friable erythematous exophytic papule has c...