A prospective study of 15 dogs with diagnosed Cushing’s syndrome was made to find a correlation between adrenal size enlargement, clinical signs and results an ACTH stimulation test. To our knowledge, no trying correlate changes in size, response therapy test results. Ultrasonographic evaluation endocrine (ACTH test/“pre pill”) were performed each dog two weeks after initiating the therapy, fou...

Hyperactivity of the hypothalamic pituitary-adrenal (HPA) axis plays a role in the pathophysiology of major depressive disorder (MDD). Recent studies suggest the role of the glutamatergic system in the pathophysiology of MDD, and N-methyl-D-aspartate (NMDA) receptor antagonists have shown antidepressant effects in both preclinical and clinical studies. However, little is known about the role of...

BACKGROUND Frail elderly people are at increased risk of death and disability from minor environmental stresses such as infection because they do not have the reserves to respond and maintain adequate homeostasis Studies have shown that elderly patients had a significantly smaller response to ACTH stimulation test. Due to paucity of data regarding HPA axis functioning in frail elderly in Indian...

Negative transfer from active to passive avoidance training. was evident 24 h after active avoidance acquisition in hypox, adx, and sham-operated rats injected with ACTH, corticosterone, or saline prior to 24-h test. No transfer was observed in control rats or in hypox, adx, or sham rats given corticosterone or saline 211z h after active avoidance training. However, hypox, adx, or sham-operated...

BACKGROUND There are no clear treatment guidelines for dogs with clinically well-regulated hyperadrenocorticism in which serum cortisol concentrations before and after an ACTH stimulation test performed 3-6 hours after trilostane administration are < 2.0 μg/dL. OBJECTIVE To determine if serum cortisol concentrations measured before (Pre1) and after (Post1) ACTH stimulation at 3-6 hours after ...

the goal of this study was to evaluate the effects of quercetin and acth injection on prevention of development of morphine tolerance and dependence in mice. in this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), acth (1, 2.5, 5 iu/mice, i.p.), or combination of quercetin (5 mg/kg) and acth (1 iu/mice) once a day for four days. tolerance ...

Elevated levels of corticotropin (ACTH)-reactive immunoglobulins (ACTH IgG) were found in males with conduct disorder, suggesting their involvement in the biology of antisocial behavior. We first aimed to confirm these findings in a large general population sample of adolescents. Secondly, we studied the association between ACTH IgG levels and hypothalamic-pituitary-adrenal (HPA) axis response ...

Forty-eight patients receiving glucocorticoid treatment were tested with ACTH stimulation using alpha(1, 24) ACTH (tetracosactrin). All patients subsequently underwent non-acute major surgery without any glucocorticoid administration, and their clinical course and plasma corticosteroids were followed closely. No case of adrenocortical insufficiency was observed. A highly significant correlation...