Background: Iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. For many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. The aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin C, as an absorbent factor of Fe, in ‎changing the serum level of iron in iron overload r...

Patients presenting to the emergency department (ED) after medication overdose are often given activated charcoal initially for gastrointestinal decontamination. Complications of charcoal are rare, but do occur. The following case describes a patient with pre-existing undiagnosed diverticular disease who developed sigmoid perforation after a single dose of activated charcoal, given without cath...

BACKGROUND Activated charcoal is commonly used to manage overdose or accidental ingestion of medicines. This study evaluated the effect of activated charcoal on apixaban exposure in human subjects. METHODS This was an open-label, three-treatment, three-period, randomized, crossover study of single-dose apixaban (20 mg) administered alone and with activated charcoal given at 2 or 6 h post-dose...

Introduction: Adsorption capacity of activated charcoal to paracetamol was determined at simulated gastric environment, pH 3.4 and simulated intestinal environment pH 7.2. Three formulations of activated charcoal; powder, capsule and suspension were tested. Paracetamol was derived from tablet to simulate in vivo intoxication conditions. Methods: Activated charcoal and paracetamol were mixed at ...

Neutralization represents an important goal in toxicology, reducing exposure to poison being crucial in any management plan of any intoxication. Controversial data actually exists in the literature regarding activated charcoal capacity to bind organophosphates. To determine and compare organophosphate binding capabilities for different hydrophobic substances, considered to have neutralising pro...

background: there is no clear data on the adherence of emergency medical services (ems) paramedics and hospital staff rather than those working in poisoning centers to the guidelines for managing acutely poisoned patients in developing countries. methods: during a 6-month period, all ems-managed poisoned patients along with those initially managed in a non-poisoning center before being referred...

There has been much debate about the use of activated charcoal in patients who have taken overdoses and then present to Emergency Departments. There are clinical trials, research and position statements that have examined the effectiveness of activated charcoal in a number of overdoses of different medications, but there is still a debate surrounding the evidence based practice of administering...

Diazepam ingestion along with ethanol is encountered commonly in drug overdose cases. In the present study, the effect of pH and ethanol on the adsorption of diazepam in the simulated gastric fluid and the simulated intestinal fluid onto activated charcoal was determined in vitro. The adsorption behaviors of diazepam in both simulated gastric and intestinal pH onto activated charcoal were studi...

the importance of the use of activated charcoal tubes for sampling gases and vapors is very well-known. for producing these tubes in the country, their production started in the laboratory of the department of occupation al health using activated charcoal, polyurethane foam and glass wool and consequently two types of foamed and foamless tubes were produced. to investigate the quality of the ra...