نتایج جستجو برای: active site cavity

تعداد نتایج: 828256  

Journal: :Organic & biomolecular chemistry 2005
Richard Daniellou Christopher P Phenix Pui Hang Tam Michael C Laliberte David R J Palmer

Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis is shown to have a nonpolar cavity adjacent to the active site, allowing racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high apparent stereoselectivity.

Journal: :Biochemistry 2004
Sijiu Liu Zhibing Lu Ying Han Yong Jia Andrew Howard Debra Dunaway-Mariano Osnat Herzberg

Previous work has indicated that PEP mutase catalyzes the rearrangement of phosphoenolpyruvate to phosphonopyruvate by a dissociative mechanism. The crystal structure of the mutase with Mg(II) and sulfopyruvate (a phosphonopyruvate analogue) bound showed that the substrate is anchored to the active site by the Mg(II), and shielded from solvent by a large loop (residues 115-133). Here, the cryst...

Journal: :Acta crystallographica. Section D, Biological crystallography 2006
Maria Solà Devin L Drew Alexandre G Blanco F Xavier Gomis-Rüth Miquel Coll

PhoB is an Escherichia coli transcription factor from a two-component signal transduction system that is sensitive to limiting environmental phosphate conditions. It consists of an N-terminal receiver domain (RD) and a C-terminal DNA-binding domain. The protein is activated upon phosphorylation at the RD, an event that depends on Mg(2+) binding. The structure of PhoB RD in complex with Mg(2+) i...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2015
Masao Iwamatsu

The line-tension effects on heterogeneous nucleation are considered when a spherical lens-shaped nucleus is nucleated on top of a spherical substrate and on the bottom of the wall of a spherical cavity. The effect of line tension on the nucleation barrier can be separated from the usual volume term. As the radius of the substrate increases, the nucleation barrier decreases and approaches that o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Tomoo Shiba Yasutoshi Kido Kimitoshi Sakamoto Daniel Ken Inaoka Chiaki Tsuge Ryoko Tatsumi Gen Takahashi Emmanuel Oluwadare Balogun Takeshi Nara Takashi Aoki Teruki Honma Akiko Tanaka Masayuki Inoue Shigeru Matsuoka Hiroyuki Saimoto Anthony L Moore Shigeharu Harada Kiyoshi Kita

In addition to haem copper oxidases, all higher plants, some algae, yeasts, molds, metazoans, and pathogenic microorganisms such as Trypanosoma brucei contain an additional terminal oxidase, the cyanide-insensitive alternative oxidase (AOX). AOX is a diiron carboxylate protein that catalyzes the four-electron reduction of dioxygen to water by ubiquinol. In T. brucei, a parasite that causes huma...

Journal: :Biochemistry 1996
J P Schanstra I S Ridder G J Heimeriks R Rink G J Poelarends K H Kalk B W Dijkstra D B Janssen

Conversion of halogenated aliphatics by haloalkane dehalogenase proceeds via the formation of a covalent alkyl-enzyme intermediate which is subsequently hydrolyzed by water. In the wild type enzyme, the slowest step for both 1,2-dichloroethane and 1,2-dibromoethane conversion is a unimolecular enzyme isomerization preceding rapid halide dissociation. Phenylalanine 172 is located in a helix-loop...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
S J Riedl P Fuentes-Prior M Renatus N Kairies S Krapp R Huber G S Salvesen W Bode

Caspases form a family of proteinases required for the initiation and execution phases of apoptosis. Distinct proapoptotic stimuli lead to activation of the initiator caspases-8 and -9, which in turn activate the common executioner caspases-3 and -7 by proteolytic cleavage. Whereas crystal structures of several active caspases have been reported, no three-dimensional structure of an uncleaved c...

Journal: :Angewandte Chemie 2003
Md Akhtarul Alam Munirathinam Nethaji Manabendra Ray

Molecule and molecular assemblies with cavities of different size and shape to encapsulate guest molecules have been synthesized in view of their potential use as selective hosts for anion sensing, catalysis, selective recognition, and separation of guest molecules.[1] Rebek, Jr. and co-workers recently demonstrated that the binding of a reagent inside a capsular cavity boosts the rate of a Die...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شیراز - دانشکده علوم 1390

any change in the refractive index of a laser active medium can lead to serious degradation of beam quality, laser beam modes, laser performance and variation in the intensity distribution. alteration in the refractive index of laser active medium is especially notable in high power lasers. it is clear that in the laser beam production, the pumping agent induces a great amount of heat which...

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